MTAP基因多态性rs3802392与缺血性卒中的关系

目的：探讨甲硫腺苷磷酸化酶（ Methylthioadenonine Phosphorylase，MTAP）基因多态性rs3802392与缺血性卒中的相关性。方法：采用聚合酶链式反应和限制性片段长度多态性（ PCR-RFLP ）方法对273例缺血性卒中患者和344例健康人的 rs3802392进行基因分型，并用 Logistic 回归方法分析其与缺血性卒中的关系。结果：MTAP 基因rs3802392基因型和等位基因频率在病例组和对照组的分布差异有统计学意义，MTAP基因rs3802392位点GA＋GG基因型是缺血性卒中发病的独立危险因素。结论：MTAP基因rs3802392可能在缺血性卒中的发病中起一定作用。

ReIationship between PoIymorphisms of MethyIthioadenosine PhosphoryIase Gene and Ischemic Stroke

ObjectiVe：To inVestigate the relationship between single nucleotide polymorphism（ SNP）rs3802392 in methyl-thioadenosine phosphorylase（ MTAP）gene and ischemic stroke. Methods：SNP rs3802392 was genotyped among 273 patients with ischemic stroke and 344 normals as control group by polymorphism chain reaction（ PCR）and restriction fragment length pol-ymorphism（ RFLP）method. And the association of rs3802392 with ischemic stroke was analyzed using Logistic regression. Re-suIts：The significant differences in allele and genotype frequencies were detected between the case group and the control group, and GA＋GG genotype was the independent risk factor for ischemic stroke. ConcIusion：SNP rs3802392 in MTAP gene may play a role in the deVelopment of ischemic stroke.