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| HPLC法测定人血浆中头孢克洛浓度 | |
| 引用本文： | 张静,赵悦,刘广余,李健华,江翊国.HPLC法测定人血浆中头孢克洛浓度[J].药学与临床研究,2002,10(3):11-13. |
| 作者姓名： | 张静 赵悦 刘广余 李健华 江翊国 |
| 作者单位： | 1. 南京医科大学第一附属医院,南京,210029 2. 徐州医学院,徐州,221002 3. 苏州市儿童医院,苏州,215003 |
| 摘 要： | 目的:采用高效液相色谱法测定人血浆中头孢克洛浓度。方法:以头孢拉定为内标,HPLC法测定。结果:头孢克洛的线性范围为0.25～30μg/ml,回归方程为y=0.1105+0.0817x,r=0.9995,最低检测浓度为0.125μg/ml,日内RSD为1.61％～3.54％,日间RSD为2.15％～5.08％。结论:主要药代动力学参数与文献报道相似。 |
| 关 键 词： | 头孢克洛 高效液相色谱 血药浓度 药代动力学 |
| 修稿时间： | 2001年11月1日 |
Determination of Cefaclor in Human Plasma by HPLC |
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| Zhang Jing,Li Jianhua,Zhao Yue,Jiang Yiguo,Liu Guanyu The No.Determination of Cefaclor in Human Plasma by HPLC[J].Pharmacertical and Clinical Research,2002,10(3):11-13. | |
| Authors: | Zhang Jing Li Jianhua Zhao Yue Jiang Yiguo Liu Guanyu The No |
| Institution: | Zhang Jing,Li Jianhua,Zhao Yue,Jiang Yiguo,Liu Guanyu The No. 1 Affiliated Hospital of Nanjing Medical University |
| Abstract: | AIM A HPLC method was established for the determination of cefaclor in human plasma. METHOD Cefradine was used as internal standard. HPLC method was used. RESULTS The range of calibration was 0. 25-30 ?g/ml(y=0. 1105 + 0. 0817x,r = 0. 9995). The minimal detectable drug concentration in plasma was 0. 125 ng/ml. RSD whinin-day was 1. 61% - 3. 54%. RSD day-today was 2. 15%-5. 08%. CONCLUTION The pharmacokinetic parameters are similar to those reported in foreign journals. |
| Keywords: | Cefaclor HPLC Pharmacodinetics Plasma drug concentration |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |