The effect of azelastine and some other antiasthmatic and antiallergic drugs on calmodulin and protein kinase C |
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Authors: | E. Middleton Jr. P. Ferriola G. Drzewiecki R. Duane Sofia |
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Affiliation: | (1) Department of Medicine State University of New York at Buffalo, 14214 Buffalo, NY, USA;(2) Wallace Laboratories, 08512 Cranbury, New Jersey, USA |
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Abstract: | The antiallergic and antiasthmatic drug, azelastine, interacts strongly with calmodulin (but not bovine serum albumin) as determined by an indirect assay; it also moderately inhibited the Ca2+-calmodulindependent enzyme bovine brain phosphodiesterase. Ketotifen was less active than azelastine in both assays of calmodulin reactivity and both drugs were less active than the recognized calmodulin inhibitor, W-7. Neither azelastine nor ketotifen had any inhibitory effect on the Ca2+- and phospholipid-dependent protein kinase C. A number of other commonly employed antiallergic and antiasthmatic drugs were essentially inactive in the calmodulin assays and had no or marginal inhibitory effect on protein kinase C. |
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