Response to suxamethonium in a myasthenic patient during remission |
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Authors: | M. ABEL J. B. EISENKRAFT N. PATEL |
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Affiliation: | Department of Anesthesiology, Mount Sinai Medical Center, New York, New York 10029-6574. |
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Abstract: | A cumulative dose followed by an infusion was used to determine the dose response to suxamethonium in a patient with diagnosed myasthenia gravis who was in true remission (asymptomatic while receiving no therapy). The ED50 and ED90 values for suxamethonium were 0.08 mg/kg and 0.20 mg/kg, and an infusion rate of 3.2 mg/kg/hour was required to maintain a 90-95% depression of the single twitch response as monitored by integrated electromyography. These values are within the range for normal patients, and we conclude that myasthenic patients during a true remission may not demonstrate resistance to suxamethonium. |
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Keywords: | Complications myasthenia gravis Measurement techniques electromyography, neuromuscular blockade Neuromuscular relaxants suxamethonium |
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