Serum concentrations of interleukin-6 in patients following unilateral versus bilateral total knee arthroplasty |
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Authors: | Hajime Kugisaki Motoki Sonohata Mitsunori Komine Kenji Tsunoda Shinsuke Someya Hidefumi Honke Masaaki Mawatari Takao Hotokebuchi |
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Institution: | (1) Department of Orthopedic Surgery, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan |
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Abstract: | Background Surgical stress is known to affect body temperature, white blood cell (WBC) count, C-reactive protein (CRP), and interleukin-6
(IL-6). The aim of the present study was to investigate which parameter is most suitable for quantitative analysis of surgical
stress.
Methods Unilateral total knee arthroplasty (U-TKA) and bilateral TKA (B-TKA) were selected for the subjects of this study because
the B-TKA creates approximately double the surgical stress of the U-TKA. The temperature, WBC count, CRP, and IL-6 in the
blood were measured pre- and postoperatively in both groups. The IL-6 in the drainage fluid was also measured after the operation.
Results The temperature, WBC count, CRP, and IL-6 in the blood significantly increased on the first day after the operation in both
groups. There were significant differences between the two groups in the WBC count (P < 0.05) and the IL-6 level in the blood (P < 0.05) on the first day after the surgery. There were no significant differences between the two groups for the CRP and
IL-6 levels in the drainage fluid. The relative proportions — (B-TKA/U-TKA) × 100 (%) — were 170.4% for the operating time,
219.4 % for total blood loss, 200.0% for blood transfusion, 100.3% for temperature, 128.9% for WBC count, 127.4% for CRP,
and 246.5% for the IL-6 level in the blood.
Conclusions The serum IL-6 level may best reflect surgical stress and could therefore be a quantitative marker of surgical stress. |
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