| 红毛五加总苷对脑缺血大鼠学习记忆障碍的影响 |
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| 引用本文： | 王欣,鞠洋,焦海胜,党月兰. 红毛五加总苷对脑缺血大鼠学习记忆障碍的影响[J]. 中华中医药杂志, 2008, 23(10) |
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| 作者姓名： | 王欣 鞠洋 焦海胜 党月兰 |
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| 作者单位： | [1]兰州大学第二医院,兰州730030 [2]兰州大学药学院,兰州730000 |
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| 摘 要： | 目的:研究红毛五加总苷(TGA)对脑缺血大鼠学习记忆障碍的改善作用及机制.方法:采用夹闭双侧颈总动脉建立脑缺血模型,检测大鼠学习记忆能力及脑组织超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量.结果:脑缺血模型组大鼠Y-迷宫试实验中,正确反应次数明显低于假手术组(P<0.01);跳台实验中,错误次数和受电击时间明显高于假手术组(P<0.01);脑组织SOD活性低于假手术组(P<0.01)、MDA含量高于假手术组(P<0.01).TGA能明显抑制脑缺血大鼠以上指标的异常改变.结论:TGA能明显改善脑缺血所致大鼠学习记忆障碍,作用机制可能与抗氧化作用有关.
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| 关 键 词： | 红毛五加总苷 脑缺血 记忆障碍 实验研究 |
Effect of total glucosides of Acantbopanax giraldii Harms on learning and memory impairment in cerebral ischemic rats |
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| WANG Xin,JU Yang,JIAO Hai-Sheng,DANG Yue-Lan. Effect of total glucosides of Acantbopanax giraldii Harms on learning and memory impairment in cerebral ischemic rats[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2008, 23(10) |
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| Authors: | WANG Xin JU Yang JIAO Hai-Sheng DANG Yue-Lan |
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| Affiliation: | WANG Xin1,JU Yang1,JIAO Hai-Sheng1,DANG Yue-Lan2(1The Sencond Hospital of Lanzhou University,Lanzhou 730030,China,2School of Pharmacy,Lanzhou University,Lanzhou 730000,China) |
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| Abstract: | Objective:To investigate the intervention effect of total glucosides of Acanthopanax giraldii Harms(TGA) on learning and memory impairment and the mechanism in cerebral ischemic rats.Methods:The model of transient cerebral ischemic /reperfusion was made by bilateral occlusion of common carotid arteries in rats.Learning-memory ability was observed and the activities of superoxide dismutase(SOD) and the content of malondialdehyde(MDA) in brain tissue were measured in rats.Results:In Ymaze test the correct rea... |
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| Keywords: | Total gucosides of Acanthopanax giraldii Harms Cerebral ischemia Memory impairment Experitmental study |
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