VIP immunoreactive nerves and somatostatin and serotonin containing cells in Crohn's disease |
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| Authors: | Lu Shi-Jun Liu Yu-Qing Lin Jian-Shao Wu Hong-Juan Sun Yong-Hong Tan Yu-Bin |
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| Affiliation: | 1. Department of Pathology, Weifang Medical College, Weifang 261042, Shandong Province, China
2. Department of Pathology, Tianjin Medical University, Tianjin 300070, Tianjin, China |
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| Abstract: | INTRODUCTION With the progress of the studies on neuroendocrine and immunology in the gastrointestinal tract, it has been recognized that the intestinal neuroendocrine system and the immune system can influence and modulate each other and a neuroendocrine immunomodulation network in the intestine has been established[1]. Neuropeptides, such as vasoactive intestinal peptide (VIP), substance P (SP), somatostatin (SS) etc. are widely distributed in the gastrointestinal tract and they play an important role in the immunomodulation of the intestinal mucosa. |
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| Keywords: | vasoactive intestinal peptide somatostatin serotonin immunohistochemistry histomorphometry |
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