| 苯作业者遗传毒性效应的研究 |
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| 引用本文： | 周道明,姚武,许东,李娥姣,陈琛.苯作业者遗传毒性效应的研究[J].河南医学研究,1993(3). |
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| 作者姓名： | 周道明 姚武 许东 李娥姣 陈琛 |
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| 作者单位： | 郑州市职业病防治所，河南医科大学卫生系，河南医科大学卫生系，郑州市职业病防治所，河南医科大学卫生系 郑州 450053，郑州 450053 |
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| 摘 要： | 本文选择遗传学效应的染色体畸变、染色体姊妹单体互换(SCE)和微核率三指标对苯作业人群进行检测。结果表明:苯作业者在苯浓度超标的状态下工作,可导致染色体畸变率、SCE和微核率增高。且在白细胞下降前即可出现。尤其以SCE最为敏感并且与白细胞的损伤相关。建议苯的慢性毒效应检测应加入遗传学效应指标。
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| 关 键 词： | 苯 染色体畸变 染色体姊妹单体互换(SCE) 微核 |
RESEARCH OF THE GENETICAL TOXICITY EFFECT ON BENZOL WORKERS |
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| Zhou Dao-ming Li E-jiao.RESEARCH OF THE GENETICAL TOXICITY EFFECT ON BENZOL WORKERS[J].Henan Medical Research,1993(3). |
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| Authors: | Zhou Dao-ming Li E-jiao |
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| Abstract: | Three indices of the genetical effect such as chromatin abnormity.sister chromatid exchange (SCE) and micronucleus rate were detected for benzol workers. The results showed the benzol worker who worked at over-standard concentration of benzol might cause chromatin abnormity rate, SCE and micronucleus rate increased. Ths situation might be presented before the WBC declined and correlated with hurt of.WBC,in particular SCE more sensitivity. suggested that detecting the chronic toxicity effect of benzol should add some indices of the genetical effect. |
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| Keywords: | benzol chromatin abnormity sister chromatid exchange (SCE) micronucleus |
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