急性脑梗死患者血清尿酸、超敏C-反应蛋白水平的变化

目的观察急性脑梗死患者血清尿酸（UA）和超敏C-反应蛋白（hsCRP）水平变化及其临床意义。方法分别检测100例急性脑梗死患者（脑梗死组）和40例健康体检者（对照组）血清UA和hsCRP水平，脑梗死组按病灶大小和病情轻重分三组（大病灶组、中病灶组、小病灶组），采用t检验和方差分析方法比较各组UA、hsCRP水平的不同。结果脑梗死组UA（357．46±69．42）μmol／L、hsCRP（16．48±2．87）mg／L水平明显高于对照组[（235．24±71．56）μmol／L、（1．39±1．07）mg／L]（t=6．271、5．923，均P〈0．01）；脑梗死组中大、中病灶组UA和hsCRP水平明显高于小病灶组（t=3．242、2．965、3．531、4．351，均P〈0．05），大病灶组UA和hsCRP水平明显高于中病灶组（t=3．682、3．541，P〈0．05）。结论急性脑梗死患者血清UA和hsCRP水平明显增高，且对预测脑梗死病情严重程度有重要的临床价值。

Clinical value of plasma uric acid(UA) and high sensitive C-reactive protein(hsCRP) levels in diagnosis of acute cerebral infarction

Objective To investigate the changes of UA and hs-CRP levels in patients with acute cerebral infarction,and to evaluate their value for predicting acute cerebral infarction. Methods The levels of UA and hs-CRP in patients with acute cerebral infarction(n = 100) and healthy controls(n = 40) were measured respectively,And three groups were provided as the size of lesion and degree. Results The levels of UA and hs-CRP in acute cerebral infarction group were significantly higher than that in control group(P ＜0.01). The levels of both UA and hs-CRP in patients with large and medium size lesions were significantly higher than those in patients with small size lesions(P ＜0.05). The levels of both UA and hs-CRP in patients with large size lesions were significantly higher than those in patients with medium size lesions(P＜0.05). Conclusion The levels of UA and hs-CRP in patients with acute cerebral infarction increase significantly,the levels of UA and hs-CRP are closely correlated with the degree of cerebral infarction,which may be of great value in predicting acute cerebral infarction and the severity of cerebral infarction.