| Notch信号转导通路与肿瘤分子靶向治疗研究进展 |
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| 引用本文： | 张辉,叶颖江,王杉.Notch信号转导通路与肿瘤分子靶向治疗研究进展[J].国际外科学杂志,2010,37(11). |
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| 作者姓名： | 张辉 叶颖江 王杉 |
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| 作者单位： | 北京大学人民医院胃肠外科,北京,100044 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | Notch信号转导通路与细胞增生、分化、凋亡密切相关,与肿瘤的关系日益受到关注,以Notch通路为靶点的肿瘤治疗策略显示了其广阔的应用前景.本文将从肿瘤中Notch通路的调控、分子靶向治疗机制及应用进展方面做一综述.
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| 关 键 词： | 信号转导 肿瘤 分子靶向治疗 |
Molecular targeted therapy for carcinoma based on Notch signal transduction pathway |
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| ZHANG Hui,YE Ying-jiang,WANG Shan.Molecular targeted therapy for carcinoma based on Notch signal transduction pathway[J].International Journal of Surgery,2010,37(11). |
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| Authors: | ZHANG Hui YE Ying-jiang WANG Shan |
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| Abstract: | The Notch signaling pathway represents control cell proliferation, differentiation and apoptosis during development.Aberrant activation of this pathway contributes to tumorigenesis and genes in the Notch signaling pathway could be potential therapeutic targets.This review involves regulation of Notch pathway and molecular targeted therapy. |
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| Keywords: | Notch |
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