原发性青光眼患者一级亲属患病筛查

目的筛查原发性青光眼患者40岁以上一级亲属原发性青光眼的患病情况,探讨如何有效早期发现原发性青光眼的方法。方法邀请2009年5月-2010年10月在潍坊眼科医院确诊的313例原发性青光眼患者的一级亲属（≥40岁）来医院进行视力、眼压、裂隙灯、直接眼底镜、眼底照相检查,部分接受了Goldmann前房角镜、中心30°视野检查。结果计划检查对象1 631人,实际受检483人,受检率为29.61%。94例原发性青光眼患者的一级亲属总患病率为7.25%。原发性闭角型青光眼（PACG）患者一级亲属的青光眼患病率随年龄增加而增高（经线性趋势的卡方检验,χ2=5.37,P=0.02）,但不同年龄组间患病率差异无统计学意义（经Fisher确切概率法,P=0.08）;原发性开角型青光眼（POAG）患者一级亲属的青光眼患病率与年龄亦有线性关系（经线性趋势的卡方检验,χ2=4.61,P=0.03）,其患病率差异有统计学意义（经Fisher确切概率法P=0.03）。男、女性之间,原发性闭角型和原发性开角型青光眼患者一级亲属青光眼的患病率差异有统计学意义（χ2=5.29,4.39;P=0.02,0.04）,而原发性青光眼患者一级亲属青光眼的患病率与性别未见明显的相关性。POAG确诊年龄18～78（51.4±13.3）岁,PACG确诊年龄43～82（66.6±8.2）岁,差异有统计学意义（Z=7.64,P〈0.01）。结论原发性青光眼患者40岁以上一级亲属患病率明显高于普通人群,因此对原发性青光眼患者一级亲属进行筛查是早期发现原发性青光眼患者的有效途径。

Screening of patients with primary glaucoma in the first degree relatives

Objective To screen primary glaucoma in the first degree relatives aged>or=40 years,exploring effective methods of detecting glaucoma earlier.Methods All the first degree relatives of 313 patients with primary glaucoma who were diagnosed in Weifang eye hospital from May 2009 to October 2010 were enrolled to accept screening test,including visual acuity,intraocular pressure(IOP),anterior chamber depth,evaluation of the optic disc.gonioscopy and perimetry were performed in defined individuals.Results In this ...