|
|||||
|
|
HIV-related cognitive impairment shows bi-directional association with dopamine receptor DRD1 and DRD2 polymorphisms in substance-dependent and substance-independent populations |
|
| Authors: | Michelle M. Jacobs Jacinta Murray Desiree A. Byrd Yasmin L. Hurd Susan Morgello |
| Affiliation: | 1. Departments of Neurology, The Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, Box 1065, New York, NY, 10029, USA 2. Departments of Psychiatry, The Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, Box 1065, New York, NY, 10029, USA 3. Departments of Neuroscience, The Icahn School of Medicine at Mount Sinai, New York, NY, USA 4. Departments of Pathology, The Icahn School of Medicine at Mount Sinai, New York, NY, USA |
| Abstract: | It has been postulated that drugs of abuse act synergistically with HIV, leading to increased neurotoxicity and neurocognitive impairment. The CNS impacts of HIV and drug use converge on the mesocorticolimbic dopamine (DA) system, which contains two main receptor subtypes: dopamine receptors 1 (DRD1) and 2 (DRD2). DRD1 and DRD2 have been linked to substance dependence; whether they predict HIV-associated neurocognitive disorder (HAND) is unclear. Using an advanced-stage HIV+ population, we sought to determine if drug dependence impacts the contribution of DA receptor polymorphisms on neurocognition. We observed that both DRD1 and DRD2 polymorphisms were associated with opiate and cocaine dependence (P?P? |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |