脑梗死患者颈动脉粥样硬化斑块的相关因素分析

目的:探讨脑梗死患者颈动脉粥样硬化斑块形成及其稳定性的相关影响因素.方法:应用彩色多普勒超声检测脑梗死患者126例及正常对照者61例颈动脉斑块形成情况;根据超声检查结果将126例脑梗死患者分为有斑块组102例,无斑块组24例,将102例有斑块者分为稳定斑块亚组35例及不稳定斑块亚组67例;比较各组脑梗死危险因素,测量并...

An analysis on the Risk Factors of Carotid Artery Atherosclerotic Plaques in Cerebral Infarction Patients

Objective:To explore the risk factors for carotid artery atherosclerotic plaques in cerebral infarction patients.Methods: Color doppler ultrasound scanner was used to detect the plaques of the carotid arteries in patients with cerebral infarction(n=126) and normal controls(n=61).According to the doppler ultrasound scanning,the patients were divided into plaque(+) group(n=102) and plaque(-) group(n=24).The patients in the plaque(+) group were further divided into stable plaque(n=35) and unstable plaque subgroups(n=67).The physical data and the concentration of total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),apolipoprotein A(ApoA),apolipoprotein B(ApoB),lipoprotein-a(Lp(a)),fibrinogen(FIB) and blood glucose(BG) were measured,and compared between the groups.Results: Carotid atherosclerotic artery plaques were detected in 80.9% of the patients,which was significantly higher than that in the normal controls(P<0.01).When compared with those in plaque(-) group,those patients were much older.Smoking,hypertension,diabetes,higher concentrations of TC,Lp(a),ApoB,FIB,LDL-C,and BG were more frequently found in the plaque(+) group.The FIB concentrations of patients in the unstable plaque subgroup was much higher that in the stable plaque subgroup(P<0.05).Conclusion: Carotid atherosclerotic plaques were the risk factor for cerebral infarction.Old age,smoking,hypertention,diabetes mellitus,lipoidosis,and high fibrinogen are the risk factors for carotid atherosclerotic plaques.High concentration of fibrinogen affects stability of the plaques.