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| CDX2和EGFR的表达与胃癌生物学行为关系的研究 | |
| 引用本文： | 方海洋,李群星,田君才,张正坤,汪龙德.CDX2和EGFR的表达与胃癌生物学行为关系的研究[J].国际消化病杂志,2011,31(2):118-120. |
| 作者姓名： | 方海洋 李群星 田君才 张正坤 汪龙德 |
| 作者单位： | 1. 甘肃省金昌市金川集团公司医院消化内科,737100 2. 甘肃省酒泉市人民医院病理科,735000 3. 甘肃省酒泉市人民医院消化内科,735000 4. 甘肃中医学院附属医院消化内科,730020 |
| 摘 要： | 目的 探讨胃癌组织中尾型同源盒转录因子-2(CDX2)、表皮生长因子受体(EGFR)的表达与胃癌临床病理的关系.方法 收集胃癌组织及相应配对癌旁组织标本各50例,采用免疫组化方法检测CDX2、EGFR的表达,分析其表达与胃癌临床病理参数的关系及意义.结果 胃癌组织中CDX2和EGFR表达率分别为78.0%和52.0%,... |
| 关 键 词： | 胃癌 免疫组化 CDX2 EGFR |
Study of the relationship between the expression of CDX2,EGFR and the biological behavior of gastric cancer |
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| FANG Hai-yang,LI Qun-xing,WANG Long-de,TIAN Jun-Cai,ZHANG Zheng-kun.Study of the relationship between the expression of CDX2,EGFR and the biological behavior of gastric cancer[J].International Journal of Digestive Disease,2011,31(2):118-120. | |
| Authors: | FANG Hai-yang LI Qun-xing WANG Long-de TIAN Jun-Cai ZHANG Zheng-kun |
| Institution: | .Department of Gastroenterology,Affiliated Hospital of Gansu College of Traditional Chinese Medicine,Lanzhou(730020),China;TIAN Jun-Cai,ZHANG Zheng-kun.The People′s Hospital of Jiuquan,Gansu(735000),China |
| Abstract: | Objective To study the relationship between expression of CDX2 and EGFR in gastric cancer tissue and clinical pathology of gastric cancer.Methods Fifty cases of gastric carcinoma and the corresponding paired adjacent tissue were collected.The expression of CDX2 and EGFR was tested using immunohistochemical method,and the relationship of its expression and clinic pathological characteristics of gastric cancer analysis.Results The expression rate of CDX2 and EGFR in gastric cancer tissues was 78.0% and 52.0%,significantly higher than adjacent tissues(54.0%,16.0%)(P<0.05).The expression of CDX2 in gastric cancer were related with Lauren classification and clinical staging(P<0.05).The expression of EGFR has positive correlation with the lymph node metastasis status and the pathological stage(P<0.05).Conclusions Both CDX2 and EGFR are involved in the occurrence and development of gastric cancer.CDX2 is expressed mainly in the intestinal-type gastric carcinoma,and may be an early event in intestinal type gastric cancer.The overexpression of EGFR can be an index of progressing and poor prognosis in gastric cancer. |
| Keywords: | CDX2 EGFR |
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