| 慢性HBV感染者甘露糖结合蛋白基因多态性与HBV基因型的关系 |
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| 引用本文： | 高建平,郑瑞丹,朱青川,林震群,洪伍华,李庆端,陈哲,蔡秀珍.慢性HBV感染者甘露糖结合蛋白基因多态性与HBV基因型的关系[J].国际检验医学杂志,2011,32(7):755-756,759. |
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| 作者姓名： | 高建平 郑瑞丹 朱青川 林震群 洪伍华 李庆端 陈哲 蔡秀珍 |
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| 作者单位： | 1. 福建省漳州市中医院,363000
2. 中国人民解放军第一七五医院,漳州,363000 |
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| 摘 要： | 目的探讨甘露糖结合蛋白(MBP)基因多态性及HBV基因型与慢性乙型肝炎(HBV)进展的关系。方法采用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)方法和实时荧光定量PCR(FQ-PCR)技术对360例慢性HBV感染者其中66例无症状HBV携带者组(ASC组)、182例慢性乙型肝炎患者组(CH组)、112例肝硬化患者组(LC组)和65例对照组]的MBP基因第54号密码子多态性和HBV基因分型进行检测。结果 ASC组和轻、中型CH组均以B基因型占优势,MBP基因GGC/GAC基因型频率和GAC等位基因频率与对照组比较差异无统计学意义(P>0.05);重型CH组、代偿期LC组、失代偿期LC组均以C基因型占优势,MBP基因GGC/GAC基因型频率和GAC等位基因频率显著高于对照组(P<0.05),其中失代偿期LC组突变率最高(37.7%)。结论该地区乙型肝炎人群以B和C基因型为主;MBP基因第54号密码子突变与HBV感染的慢性化无明显关系,而与HBV C基因型及慢性HBV感染者的肝病进展有关。
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| 关 键 词： | 基因 突变 肝炎病毒 乙型 甘露糖结合蛋白 |
The relationship of mannose binding protein(MBP)genetic polymorphisms and HBV genotype on patients with chronic HBV infection |
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| Gao Jianping,Zheng Ruidan,Zhu Qingchuan,Lin Zhenqun,Hon Wuhua,Li Qingduan,Chen Zhe,Cai Xiuzhen.The relationship of mannose binding protein(MBP)genetic polymorphisms and HBV genotype on patients with chronic HBV infection[J].International Journal of Laboratory Medicine,2011,32(7):755-756,759. |
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| Authors: | Gao Jianping Zheng Ruidan Zhu Qingchuan Lin Zhenqun Hon Wuhua Li Qingduan Chen Zhe Cai Xiuzhen |
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| Institution: | Gao Jianping1,Zheng Ruidan2,Zhu Qingchuan1,Lin Zhenqun1,Hon Wuhua1,Li Qingduan1,Chen Zhe1,Cai Xiuzhen1(1.Department of Gastroenterlogy,Chinese Traditional Medicine Hospital in ZhangZhou,Fujian Province,Zhangzhou 363000,China,2.175 Hospital in ZhangZhou,China) |
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| Abstract: | Objective To determine the influences of Mannose binding protein(MBP)genetic polymorphisms and HBV genotype on the progression of liver disease.Methods The codon 54 polymorphisms of MBP gene in a cohort of 360 patients with chronic HBV infection,including 66 with asymptomatic HBV carriers(ASC),the remaining 182 with chronic hepatitis B(CH),112 with liver cirrhosis(LC)and 65 with controls were analyzed by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)and fluorescent quantitative... |
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| Keywords: | genes mutation hepatitis B virus mannose-binding protein |
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