丙泊酚制剂引起注射部位疼痛的机制研究进展 |
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引用本文: | 陈涛,王汝涛,胡惠静,傅经国,卢婷利.丙泊酚制剂引起注射部位疼痛的机制研究进展[J].国际麻醉学与复苏杂志,2011,32(1):109-112. |
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作者姓名: | 陈涛 王汝涛 胡惠静 傅经国 卢婷利 |
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作者单位: | 1. 710072,西安,西北工业大学生命科学院;陕西省脂质体工程技术研究中心;西安力邦制药有限公司 2. 710072,西安,西北工业大学生命科学院;陕西省脂质体工程技术研究中心 3. 陕西省脂质体工程技术研究中心;西安力邦制药有限公司 |
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基金项目: | 陕西省重大科技创新项目 |
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摘 要: | 背景 丙泊酚是目前临床常用的静脉麻醉药,其具有起效快、作用时间短及安全性高的特点.但是30%~70%患者会出现注射疼痛的副作用,对患者机体和精神造成了严重影响.目的 为减轻丙泊酚临床给药疼痛提供有效的解决策略,为新制剂研发提供思路.内容 对近年来国内外学者关于丙泊酚注射疼痛机理的研究进展进行分析评述,概括导致丙泊酚注射...
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关 键 词: | 丙泊酚 注射疼痛 疼痛机制 麻醉 |
Progress on the studies of mechanism of pain on injection of propofol |
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Abstract: | Background Propofol was commonly used as intravenous anesthetics,which has a rapid onset,short duration of action and high security. But 30% to 70% of patients have side effect of pain on injection,which impact on the psychosomatic health of patient seriously.Objective To provide effective clinical therapeutic strategy for alleviating the pain of propofol administration,and provide new ideas for developing new propofol agents. Content We summarized various hypothesis and mechanisms of inducing pain on propofol injection by analyzing and reviewing the investigation and progression about the mechanism of pain on propofol injection at home and abroad.Trend From these reviews,we want to provide some suggestion and reference for treatment of pain on propofol injection |
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