| 黏着斑激酶与肿瘤 |
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| 引用本文： | 孟祥宁,王柏春,白静,傅松滨. 黏着斑激酶与肿瘤[J]. 国际遗传学杂志, 2011, 34(1). DOI: 10.3760/cma.j.issn.1673-4386.2011.01.003 |
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| 作者姓名： | 孟祥宁 王柏春 白静 傅松滨 |
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| 作者单位： | 1. 哈尔滨医科大学医学遗传学研究室,150081
2. 哈尔滨医科大学附属第一医院心外科,150001 |
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| 基金项目： | 黑龙江省自然基金，黑龙江省教育厅基金，黑龙江省博士后启动基金 |
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| 摘 要： | 黏着斑激酶(focal adhesion kinase,FAK)是近几年新发现的一种受体型酪氨酸激酶,它可以调节细胞的增殖、转移和生存等能力,它的异常表达与肿瘤的发生、发展及转移有密切的关系.研究FAK的作用机制、针对FAK靶点进行肿瘤的综合治疗,是肿瘤治疗的一个非常有前途的方向.本文对FAK在肿瘤中的表达、作用机制及其在肿瘤治疗中的应用前景作一综述.Abstract：Focal adhesion kinase ( FAK ) is a kind of newly found receptor tyrosine kinase, which can modulate the abilities of cell growth, metastasis and survival. The abnormal expression of FAK can affect the development and metastasis of cancer intimately. A promoting direction of oncotherapy can be applied by the study on FAK mechanism and FAK target. Herein, we will review the the expression of FAK, the action mechanism and the application of FAK target in cancer.
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| 关 键 词： | 黏着斑激酶 肿瘤 机制 |
Focal adhesion kinase and cancer |
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| MENG Xiang-ning,WANG Bai-chun,BAI Jing,FU Song-bin. Focal adhesion kinase and cancer[J]. International JOurnal of Genetics, 2011, 34(1). DOI: 10.3760/cma.j.issn.1673-4386.2011.01.003 |
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| Authors: | MENG Xiang-ning WANG Bai-chun BAI Jing FU Song-bin |
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| Abstract: | Focal adhesion kinase ( FAK ) is a kind of newly found receptor tyrosine kinase, which can modulate the abilities of cell growth, metastasis and survival. The abnormal expression of FAK can affect the development and metastasis of cancer intimately. A promoting direction of oncotherapy can be applied by the study on FAK mechanism and FAK target. Herein, we will review the the expression of FAK, the action mechanism and the application of FAK target in cancer. |
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| Keywords: | Focal adhesion kinase Cancer Mechanism |
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