| 血红素加氧酶-1(HO-1)基因转染治疗急性胰腺炎的研究展望 |
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| 引用本文： | 张飞虎,费健,毛恩强. 血红素加氧酶-1(HO-1)基因转染治疗急性胰腺炎的研究展望[J]. 国际外科学杂志, 2011, 38(3): 177-179. DOI: 10.3760/cma.j.issn.1673-4203.2011.03.011 |
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| 作者姓名： | 张飞虎 费健 毛恩强 |
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| 作者单位： | 上海交通大学医学院附属瑞金医院外科,上海,200025 |
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| 摘 要： | 血红素加氧酶-1(heme oxygenase-1,HO-1)通过分解血红素产生一氧化碳、胆绿素、胆红素及亚铁离子,可以减轻炎性介质反应,拮抗细胞氧化损伤和细胞应激从而发挥细胞保护作用.基因转染的方法能够维持目的基因的长时间表达,可以调节细胞因子的免疫反应.HO-1基因转染已在其他疾病的治疗研究中取得良好成果,本文针对...
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| 关 键 词： | 急性胰腺炎 血红素加氧酶-1 基因转染 |
Feasibility of heme oxygenase- 1 ( HO- 1 ) gene transfer therapy in acute pancreatitis |
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| ZHANG Fei-hu,FEI Jian,MAO En-qiang. Feasibility of heme oxygenase- 1 ( HO- 1 ) gene transfer therapy in acute pancreatitis[J]. International Journal of Surgery, 2011, 38(3): 177-179. DOI: 10.3760/cma.j.issn.1673-4203.2011.03.011 |
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| Authors: | ZHANG Fei-hu FEI Jian MAO En-qiang |
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| Abstract: | Heme oxygenase- 1 ( HO- 1 ) can catalyze the decomposition of heme and the products of its enzymatic activity,including carbon monoxide, biliverdin, bilintbin and ferritin, can play a significant cytoprotective role in antagonizing inflammation, protecting cells from oxidative injury and cellular stresses. The method of gene transfer can maintain target gene expression for a long time,can regulate the inflammatory immune response. HO- 1 gene transfer has made marked results in research of numerous diseases. In this article,we give a review of feasibility of HO-1 gene transfer therapy in acute pancreatitis. |
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| Keywords: | Acute pancreatitis Heme oxygenase-1 Gene transfer |
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