树突状细胞和CD4+CD25+调节性T细胞在免疫耐受中的作用及关系

诱导免疫耐受具有高效、低毒、经济等优点,在器官移植中有着极其重要的意义.在建立免疫耐受中,树突状细胞(DC)起到克隆清除、克隆无能、表达T细胞抑制因子、选择性激活辅助T细胞和诱导调节性T细胞尤其是CD4+CD25+调节性T细胞的产生等作用.而CD4+CD25+调节性T细胞主要以DC为作用靶点,影响其分化成熟,抑制DC向...

Function and interaction of dendritic cells and CD4+CD25+regulatory T cells in immune tolerance

Induction of immune tolerance is characterized by high efficiency,low toxicity and economic advantages,and immune tolerance has very important significance in organ transplantation.In the establishment of immune tolerance,dendritic cells (DCs) play the key roles such as clonal deletion or clonal anerge,expressing t-cell inhibiting factors,activating helper T cells electively and inducing regulatory T cells,especially CD4 + CD25 + regulatory T cells,etc.Similarly,CD4 + CD25 + regulatory T cells whose primary target point is dendritic cell also have various functions such as affecting dendritic cells'maturing,restraining dendritic cells'antigen presentation to T cells,inhibiting the activation of T cells in non-specific ways and inducing immune tolerance.Current research shows,dendritic cells and CD4 + CD25 + regulatory T cells regard each other as target point and work synergetically.Here we mainly discuss the function and interaction of dendritic cells and CD4 + CD25 + regulatory T cells in the immune tolerance.