| 髓系抑制细胞抑制机体抗肿瘤免疫机制及相关免疫治疗的研究进展 |
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| 引用本文： | 徐建,王艳红.髓系抑制细胞抑制机体抗肿瘤免疫机制及相关免疫治疗的研究进展[J].国际免疫学杂志,2011,34(2):111-114. |
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| 作者姓名： | 徐建 王艳红 |
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| 作者单位： | 复旦大学附属中山医院肝癌研究所,上海,200032 |
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| 基金项目： | 中山医院-生物医学研究院合作基金 |
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| 摘 要： | 髓系抑制细胞为未成熟的髓系细胞，在肿瘤组织中大量聚集。髓系抑制细胞可通过多种机制抑带0细胞毒性T细胞和自然杀伤细胞。自然杀伤T细胞对肿瘤的杀伤或通过诱导调节性T细胞（Treg）抑制机体抗肿瘤免疫从而促进肿瘤进展，因而抑制髓系抑制细胞将成为肿瘤免疫治疗的新靶点。
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| 关 键 词： | 髓系抑制细胞 细胞毒性T细胞 免疫治疗 |
Research advance of myeloid-derived suppressor cells on bionomics and immunosuppressive action and related immunotherapy |
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| XU Jian,WANG Yan-hong.Research advance of myeloid-derived suppressor cells on bionomics and immunosuppressive action and related immunotherapy[J].International Journal of Immunology,2011,34(2):111-114. |
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| Authors: | XU Jian WANG Yan-hong |
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| Institution: | (Liver cancer Institute, Zhongshan Hospital, Fudan U- niversity, Shanghai 200032, China) |
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| Abstract: | Myeloid-derived suppressor cells(MDSC) are immature myeloid cells that are associated with tumor progression. M DSC can suppress the killing function of cytotoxic T lymphocyte(CTL), nature killer cell(NK) and nature killer T cell(NKT) , MDSC can also induce immune tolerance to tumor antigens by expanding regulatory T cells. As MDSC can induce tumor progression by multiple mechanisms, more and more researches focus on augmenting endogenous antitumor immunity by suppressing the function of MDSC. |
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| Keywords: | Myeloid-derived suppressor cells Cytotoxic T lymphocytes Immune theraphy |
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