| 结直肠癌转移相关基因的研究现状 |
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| 引用本文： | 刘峰,李国新.结直肠癌转移相关基因的研究现状[J].国际外科学杂志,2011,38(2):117-120. |
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| 作者姓名： | 刘峰 李国新 |
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| 作者单位： | 南方医科大学附属南方医院普外科,广州,510515 |
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| 摘 要： | 结直肠癌是常见的消化道恶性肿瘤，其转移是结直肠癌患者死亡的主要原因。结直肠癌转移机制尚未完全阐明，目前研究表明，转移过程涉及多个相关基因的变化。文中就结直肠癌转移过程中癌基因C—myc、Ras、Her一2，抑癌基因p53、结肠癌中缺失基因（deletedincolorectalcarcinoma，DDC）、第10号染色体缺失的磷酸酶和张力蛋白同源物基因（phosphatase and tensin homologue deleted on chromosome 10, PTEN）、肿瘤转移抑制基因nm23以及其他编码基因，如CD44、基质金属蛋白酶（matrix metalloprofeinases，MMPs）、黏蛋白（mucins，MUC）的研究现状作一综述。
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| 关 键 词： | 结直肠肿瘤 肿瘤转移 基因 |
Metastasis-related genes in human colorectal cancer:a literature review |
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| LIU Feng,LI Guo-xin.Metastasis-related genes in human colorectal cancer:a literature review[J].International Journal of Surgery,2011,38(2):117-120. |
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| Authors: | LIU Feng LI Guo-xin |
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| Abstract: | Colorectal cancer is one of the most commonly seen malignant neoplasms in digestive tract.Most patients with colorectal cancer died of metastasis.The details of the metastasis-associated mechanisms are not elucidated completely.Recently,many genes that are involved in this course were detected.In this paper,the latest advances in those metastasis-associated genes and coding genes including C-myc,Ras,Her-2 ,p53,deleted in colorectal cancer gene (DDC),phosphatase and tensin homologue (PTEN),nm23 and other code genes,such as CD44,matrix metalloproteinases (MMPs) and mucins will be reviewed. |
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| Keywords: | Colorectal neoplasms Neoplasm metastasis Genes |
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