| 原发性醛固酮增多症的发病机制 |
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| 引用本文： | 徐媛媛,王卫庆.原发性醛固酮增多症的发病机制[J].国际内分泌代谢杂志,2011,31(2):141-144. |
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| 作者姓名： | 徐媛媛 王卫庆 |
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| 作者单位： | 上海交通大学医学院附属瑞金医院内分泌科,200025 |
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| 摘 要： | 原发性醛固酮增多症是继发性高血压最常见的原因之一,与具有相同危险程度的原发性高血压患者比较,原发性醛固酮增多症患者心、脑血管及肾脏等靶器官的损伤更为多见.近年来,随着对原发性醛固酮增多症的深入研究,发现其发病机制涉及融合基因的产生、醛固酮合成酶(CYP11β2)基因多态性的改变、肾上腺异位受体的表达及7p21-22基因...
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| 关 键 词： | 原发性醛固酮增多症 CYP11β2基因 嵌合基因 肾上腺异位受体 |
Pathogenesis of primary aldosteronism |
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| XU Yuan-yuan,WANG Wei-qing.Pathogenesis of primary aldosteronism[J].International JOurnal of Endocrinology and Metabolism,2011,31(2):141-144. |
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| Authors: | XU Yuan-yuan WANG Wei-qing |
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| Abstract: | Primary aldosteronism is one of the most common causes of secondary hypertension. Compared with essential hypertension patients who have same risk factors, impared cardiovascular, cerebrovascular and kidney damage are more prevalent in patients with primary aldosteronism. In recent years,with the further research of primary aldosteronism, it was shown that the pathogenesis of primary aldosteronism related to CYP11β2 gene polymorphisms, production of hybird gene, expression of ectopic adrenal receptors, 7p21-22gene and so on. Researches of pathogenesis of primary aldosteronism may provide a novel therapeutic strategy. |
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| Keywords: | Primary aldosteronism CYP11β2 gene Hybird gene Ectopic adrenal receptors |
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