| 肝癌微环境与调节性T细胞 |
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| 引用本文： | 胡娟,邹书兵,周凡. 肝癌微环境与调节性T细胞[J]. 国际肿瘤学杂志, 2011, 38(1). DOI: 10.3760/cma.j.issn.1673-422X.2011.01.018 |
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| 作者姓名： | 胡娟 邹书兵 周凡 |
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| 作者单位： | 南昌大学医学院研究生院,330000 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 调节性T细胞(Treg)的浸润是肿瘤免疫微环境抑制的重要机制之一.Treg在多种肿瘤患者的外周血和肿瘤组织呈现高表达,其高表达很可能通过抑制CD4+、CD8+T淋巴细胞的肿瘤杀伤效应或引起效应性T淋巴细胞对肿瘤抗原的耐受,而不产生急性或记忆性效应性T淋巴细胞反应,最终逃避免疫攻击,营造了机体免疫抑制微环境,介导肿瘤的免疫逃逸.Abstract：Regulatory T cell (Treg) infiltration is an important mechanism for inhibition of tumor immune microenvironment. Treg is highly expressed in peripheral blood and tumor tissue of various cancer patients. A high expression of Treg may inhibit the antitumor effect of CD4 + CD8 + T lymphocytes or induce immunological resistance to tumor antigens among cytotoxic T lymphocytes(CTL) without producing acute or memory CTL responses, resulting in tumor escape from immuneattack and immune suppressionin in the tumor microenvironment.
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| 关 键 词： | 肝肿瘤 抗原,分化,T淋巴细胞 肿瘤微环境 调节性T细胞 |
Microenvironment of primary liver cancer and regulatory T cells |
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| HU Juan,ZOU Shu-bing,ZHOU Fan. Microenvironment of primary liver cancer and regulatory T cells[J]. Journal of International Oncology, 2011, 38(1). DOI: 10.3760/cma.j.issn.1673-422X.2011.01.018 |
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| Authors: | HU Juan ZOU Shu-bing ZHOU Fan |
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| Abstract: | Regulatory T cell (Treg) infiltration is an important mechanism for inhibition of tumor immune microenvironment. Treg is highly expressed in peripheral blood and tumor tissue of various cancer patients. A high expression of Treg may inhibit the antitumor effect of CD4 + CD8 + T lymphocytes or induce immunological resistance to tumor antigens among cytotoxic T lymphocytes(CTL) without producing acute or memory CTL responses, resulting in tumor escape from immuneattack and immune suppressionin in the tumor microenvironment. |
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| Keywords: | Liver neoplasms Antigens,differentiation,T-lymphocyte Neoplasms microenvironment T-lymphocytes regulatory |
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