| 大肠癌的化学预防 |
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| 引用本文： | 周平,段新星,刘剑. 大肠癌的化学预防[J]. 国际肿瘤学杂志, 2011, 38(3): 224-228. DOI: 10.3760/cma.j.issn.1673-422X.2011.03.020 |
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| 作者姓名： | 周平 段新星 刘剑 |
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| 作者单位： | 1. 浙江大学医学院附属第一医院肿瘤外科,杭州,310003
2. 杭州市中医院 |
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| 摘 要： | 研究显示阿司匹林及环氧合酶-2抑制剂是最有效的大肠癌预防剂,但其消化道及心血管不良反应限制了临床应用.二氟甲基鸟氨酸与舒林酸联合应用能有效降低腺瘤复发、不良反应极少,是当前研究热点.5-氨基水杨酸及熊去氧胆酸是化学预防炎症性肠病癌变的主要研究方向.叶酸的双重调节作用仍值得探讨.他汀类及表皮生长因子受体抑制剂显示出一定疗...
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| 关 键 词： | 结直肠癌 化学预防 |
Chemoprevention of colorectal cancer |
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| ZHOU Ping,DUAN Xin-xing,LIU Jian. Chemoprevention of colorectal cancer[J]. Journal of International Oncology, 2011, 38(3): 224-228. DOI: 10.3760/cma.j.issn.1673-422X.2011.03.020 |
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| Authors: | ZHOU Ping DUAN Xin-xing LIU Jian |
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| Abstract: | Chemoprevention is the use of natural or synthetic substances to prevent、suppress or to reverse the development of colorectal cancer.Aspirin and cox-2 inhibitor are the most effective preventive agents.However,the gastrointestinal and cardiovascular adverse effects limit the application.Recurrent adenomas can be markedly reduced by a combination of difluoromethylornithine and sulinclac and with few side effects.5-aminosalicylate and ursodeoxycholic acid have become the focus of inflammatory bowel disease.The double roles of folate need further study.Statins and EGFR inhibitors have some effects,which are in early clinical studies.The article reviews the new progress of chemoprevention of colorectal cancer. |
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| Keywords: | Colorectal neoplasms Chemoprevention |
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