血必净对急性重症胰腺炎患者炎性介质的影响

目的 观察血必净注射液对急性重症胰腺炎患者炎性介质的影响.方法 将80例急性重症胰腺炎患者按病例尾号随机分为两组各40例,对照组在禁食、补液、抑酸、抗感染等治疗基础上,持续静脉泵入生长抑素6 mg,乌司他丁20万U,连续治疗7 d.治疗组在对照组治疗基础上静脉滴注血必净注射液,50 ml/次,2次/d,连用7 d.观察...

Clinical observation on effects of Xuebijing injection on inflammatory mediators of patients with severe acute pancreatitis

Objective To evaluate the effects of Xuebijing injection on inflammatory mediators of patients with severe acute pancreatitis. Methods Using double blind method, 80 cases with severe acute pancreatitis were randomly divided into two groups, with 40 cases in each group. The control group was treated with conventional therapy such as: fasting, fluid replacement, acid inhibition and anti-infection, combined with the continuing injection with the growth hormone release inhibiting 6 mg, ulinastatin 200000u for 7 days. Based on the control group's treatment, the other group was added with Xuebijing injection 50 ml, twice a day for 7days. The plasma levels of prostaglandin Ⅰ2 (PGI2), thromboxane A2 (TXA2), tumor necrosis factor α (TNFα),interleukin-1,6,8 (IL-1,6,8) were compared before and after the treatment in each group and between two groups.Results Compared with the control group, Xuebijing injection group had marked effects on modulating the levels of inflammatory mediators. The levels of PGI2 and PGI2/TXA2 were increased significantly and the levels ofTXA2, TNF2, IL-1,6 and 8 were deceased(P＜0.05)sharply after the treatment. Conclusion Combined with conventional western medicine therapy, Xuebijing injection has the effects of inhibiting and controlling the release of inflammatory mediators on patients with severe acute pancreatitis.