Physico-chemical stability and sterility of non-opioid analgesics in solution |
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| Authors: | Troïtzky A Tirault M Lefeuvre S Lepage B Debaene B |
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| Affiliation: | 1. Département d’anesthésie-réanimation, hôpital Jean-Bernard, 2, rue de la Milétrie, BP 577, 86021 Poitiers cedex, France;2. Département d’anesthésie-réanimation, clinique St-Paul, 4, rue des Hibiscus-Clairière, 97200 Fort-de-France, Martinique;3. Laboratoire de pharmacocinétique, hôpital Jean-Bernard, 2, rue de la Milétrie, BP 577, 86021 Poitiers cedex, France;4. Département d’informations médicales, hôpital Jean-Bernard, 2, rue de la Milétrie, BP 577, 86021 Poitiers cedex, France |
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| Abstract: | ObjectivesThe combination of non-opioid analgesic drugs (P: paracetamol, K: ketoprofen and N: nefopam) is currently recommended for postoperative pain control. In practice, these analgesics are often administered in the same solution. We investigated the chemical stability and sterility of three mixtures of analgesics (P + K, P + N and K + N).MethodsFor each mixture, concentrations of active principles were measured using high-performance liquid chromatography over 24 hours. These mixtures were cultured for microbiological colonization.ResultsOur study demonstrated chemical and bacteriologic stability of these three mixtures over a 24-hour period. The results allow the use of P + K, P + N and K + N in the same ready to use solution. |
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| Keywords: | Analgésie postopératoire multimodale Paracétamol Kétoprofène Néfopam Stabilité pharmacologique et bactériologique |
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