| 抗核抗体标载的131I近距离放疗治疗脑深部小体积胶质瘤探讨 |
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| 引用本文： | 赵明,傅相平,张志文,梁树立,李安民.抗核抗体标载的131I近距离放疗治疗脑深部小体积胶质瘤探讨[J].军医进修学院学报,2011,32(12):1201-1203. |
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| 作者姓名： | 赵明 傅相平 张志文 梁树立 李安民 |
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| 作者单位： | 解放军总医院第一附属医院神经外科,北京,100048 |
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| 摘 要： | 目的 分析131I-chTNT近距离放疗治疗脑深部小体积胶质瘤的疗效.方法 我科收治25例脑深部小体积(直径＜4cm)脑胶质瘤患者,利用立体定向法进行活检并放置Ommaya囊,术后给予131I-chTNT近距离放疗,每月复查核磁并进行随访.结果 显效(病灶消失)4例,有效(缩小50％以上)7例,无效(肿瘤直径变化50％以内)4例,恶化(增大超过50％)10例,有效率44％.2月后患者出现不同程度甲状腺功能低下,口服甲状腺素片后激素水平稳定.结论 131I-chTNT近距离放疗治疗脑深部小体积胶质瘤效果肯定,进一步完善后有望成为治疗脑深部小体积胶质瘤的有效方法.
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| 关 键 词： | 胶质瘤 碘131 近距离放疗 |
131I-chTNT brachytherapy for deep-seated small glioma |
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| ZHAO Ming
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FU Xiang-ping
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ZHANG Zhi-wen
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LIANG Shu-li
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LI An-min.131I-chTNT brachytherapy for deep-seated small glioma[J].Academic Journal of Pla Postgraduate Medical School,2011,32(12):1201-1203. |
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| Authors: | ZHAO Ming FU Xiang-ping ZHANG Zhi-wen LIANG Shu-li LI An-min |
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| Institution: | Department of Neurosurgery,First Affiliated Hospital of Chinese PLA General Hospital,Beijing 100048,China |
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| Abstract: | Objective To analyze the effect of 131I-chTNT brachytherapy for deep-seated small glioma.Methods Twenty patients with deep-seated small glioma（〈4cm） who underwent stereotactic biopsy and Ommaya reservoir implantation in our department were enrolled in this study.They were given 131I-chTNT brachytherapy after operation,reexamined by MRI every month and followed up.Results 131I-chTNT brachytherapy was significantly effective for 4 patients,effective for 7 patients,ineffective for 4 patients,and deteriorated the disease in 10 patients,with a total effective rate of 44%.Different degrees of hypothyroidism were observed in patients 2 months after 131I-chTNT brachytherapy and their thyroid hormone level became stable after taking thyroxin tablets.Conclusion 131I-chTNT brachytherapy is effective for deep-seated small glioma. |
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| Keywords: | glioma ^1311 brachytherapy |
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