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| NONMEM法分析丙泊酚靶控输注在老年手术患者的群体药效学 | |
| 引用本文： | 许川雅,蒋建渝,吴新民,卢炜. NONMEM法分析丙泊酚靶控输注在老年手术患者的群体药效学[J]. 中国临床药理学杂志, 2007, 23(4): 304-307 |
| 作者姓名： | 许川雅 蒋建渝 吴新民 卢炜 |
| 作者单位： | 1. 北京大学第三医院麻醉科,北京100083 2. 北京大学第一医院麻醉科,北京100034 3. 北京大学医学部药学院,北京100083 |
| 摘 要： | 目的研究丙泊酚靶控输注用于老年患者的群体药效学。方法32例择期下腹部开腹手术的患者,麻醉诱导和维持均用TCI丙泊酚(血浆浓度为3μg.mL-1),以反相高效液相色谱-荧光法测定丙泊酚的血浆浓度。用NONMEM软件对老年患者丙泊酚群体药效学进行分析。结果以BIS值作为药效学指标,用左旋滞后回线药代动力学/药效学(PK/PD)链式模型,建立血药浓度与药效间的定量关系。结论中国人老年患者的Keo和EC50分别为0.13min-1,3.77μg.mL-1。 |
| 关 键 词： | 丙泊酚 靶控输注 群体药效学 反相高效液相色谱-荧光法 |
| 文章编号： | 1001-6821（2007）04-0304-04 |
| 修稿时间： | 2005-12-152007-02-07 |
Pharmacodynamics of propofol administered by target controlled infusion in Chinese elderly operation patients by NONMEM |
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| XU Chuan-ya,JIANG Jian-yu,WU Xin-min,LU Wei. Pharmacodynamics of propofol administered by target controlled infusion in Chinese elderly operation patients by NONMEM[J]. The Chinese Journal of Clinical Pharmacology, 2007, 23(4): 304-307 | |
| Authors: | XU Chuan-ya JIANG Jian-yu WU Xin-min LU Wei |
| Affiliation: | 1. Peking University Third Hospital, Department of Anesthesiology, Beijing 100083, China ;2. Department of Anesthesiology, Peking University First Hos- pital, Beijing 100034, China ; 3. Peking University School of Pharmaceutical Science, Beijing 100083, China |
| Abstract: | |
| Keywords: | propofol target-controlled infusion population pharmacodynamics RP-HPLC-fluorescence |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |