p38丝裂原活化蛋白激酶与慢性气道疾病

支气管哮喘和慢性阻塞性肺疾病是两大主要的慢性气道疾病.作为一种细胞内信号转导通路,p38丝裂原活化蛋白激酶(MAPK)介导基因表达、炎性因子产生,在炎性细胞的增殖、分化、凋亡等方面扮有关键性作用,参与慢性气道疾病的气道炎症机制.体外实验表明p38 MAPK抑制剂有抗炎作用,动物实验表明p38 MAPK抑制剂可有效抑制慢性气道疾病模型的气道炎症、气道高反应性和重塑.此外,p38 MAPK的活性异常还与激素不敏感密切相关,p38 MAPK抑制剂可提高激素的抗炎效应.

p38 mitogen activated protein kinase and chronic airway disease

Bronchial asthma and chronic obstructive pulmonary disease are two major forms of chronic airway disease. As an intracellular signalling pathway, p38 mitogen activated protein kinase (MAPK) mediates gene expression and cytokine production, plays a key role in the proliferation, differentiation,apoptosis of inflammatory cells and involves in the airway inflammation in chronic airway disease. In vitro studies showed anti-inflammatory function of p38 MAPK inhibitor and animal model studies indicated that p38 MAPK inhibitor effectively inhibits airway inflammation, airway hyperresponsiveness and remodelling in the chronic airway disease model. In addition, the overactivity of p38 MAPK is associated with steroids insensitivity and p38 MAPK inhibitor improves the anti-inflammatory effect of steroids.