| 内分泌腺来源的血管内皮生长因子在多囊卵巢中的表达及意义 |
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| 引用本文： | 吴丽姝,任凤岩,王春晓,卜素芝,王丹波. 内分泌腺来源的血管内皮生长因子在多囊卵巢中的表达及意义[J]. 中国实用医药, 2011, 6(5): 25-27 |
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| 作者姓名： | 吴丽姝 任凤岩 王春晓 卜素芝 王丹波 |
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| 作者单位： | 1. 黑龙江省大庆市人民医院妇产科,163316
2. 中国医科大学附属盛京医院妇产科 |
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| 摘 要： | 目的研究内分泌腺来源的血管内皮生长因子(EG-VEGF)在多囊卵巢的表达,并与血管内皮生长因子(VEGF)的表达进行比较,探讨EG-VEGF在多囊卵巢综合征(PCOS)发病机制中的作用。方法采用免疫组化SP法检测多囊卵巢及正常卵巢组织中EG-VEGF及VEGF的表达情况。结果 EG-VEGF在研究组中的表达水平显著高于对照组(P=0.001)。VEGF在研究组中的表达水平明显高于对照组(P=0.021)。研究组中EG-VEGF的表达水平高于VEGF的表达水平(P=0.036),二者表达无相关性(P=0.327)。对照组中EG-VEGF的表达水平略高于VEGF的表达水平,但差异无统计学意义(P=0.655),二者表达仍无相关性(P=0.928)。结论 EG-VEGF蛋白的过度表达促进多囊卵巢综合征患者的血管生成,与多囊卵巢综合征的发生相关。
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| 关 键 词： | 多囊卵巢综合征 内分泌腺来源的血管内皮生长因子 血管内皮生长因子 免疫组化 |
The expression and significance of endocrine gland-derived vascular endothelial growth factor in polycystic oraries |
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| WU Li-shu,REN Feng-yan,WANG Chun-xiao,et al.. The expression and significance of endocrine gland-derived vascular endothelial growth factor in polycystic oraries[J]. China Practical Medical, 2011, 6(5): 25-27 |
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| Authors: | WU Li-shu REN Feng-yan WANG Chun-xiao et al. |
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| Affiliation: | WU Li-shu,REN Feng-yan,WANG Chun-xiao,et al.Department of Obstetrics and Gynecology,The People's Hospital of Daqing HeiLongJiang,163316,China |
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| Abstract: | Objective To research the expression of EG-VEGF in polycystic ovaries and compare with VEGF,in order to explore the role of EG-VEGF in development and progression of PCOS.Methods The expression of EG-VEGF and VEGF in polycystic ovaries and normal ovarian tissues were detected by immunohistochemistry.Results The expression levels of EG-VEGF in the study group were significantly higher than those in the control group(P=0.001).The expression levels of VEGF in the study group were significantly higher than thos... |
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| Keywords: | Polycystic ovary syndrome EG-VEGF VEGF Immunohistochemistry |
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