| 乳腺癌组织中—p—MAPK活化对c—fos和c—jun的激活作用 |
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| 摘 要： |
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| 关 键 词： | 乳腺癌 丝裂素激活 蛋白激酶 磷酸化 癌基因 信号传导 |
Effect of activation of p-MAPK on activating c-fos and c-jun proteins in breast cancer] |
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| R X Cheng,D Y Feng,H Zheng,Y Tan. Effect of activation of p-MAPK on activating c-fos and c-jun proteins in breast cancer][J]. Bulletin of Hunan Medical University, 2001, 26(1): 10-12 |
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| Authors: | R X Cheng D Y Feng H Zheng Y Tan |
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| Affiliation: | Department of Hematology, Xiangya Medical College, Central South University, Changsha 410078. |
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| Abstract: | OBJECTIVE: This paper was to investigate the relationship between expression of p-MAPK and oncogenesis of breast cancer. METHODS: Immunohistochemical technique was used to detect the expression of p-MAPK and c-fos and c-jun proteins in 68 cases of breast cancers, 42 cases of pericarcinomatous tissues and 7 cases of normal breast tissues. RESULTS: Positive stainings of p-MAPK, c-fos, and c-jun were localized in cancer cell nuclei. The positive rates of p-MAPK, c-fos, and c-jun were 86.8% (59/68), 82.4% (56/68), and 77.9% (53/68), respectively, which were much higher than that in pericarcinomatous tissues (P < 0.01). Of some cases, p-MAPK positive staining was also found in the nuclei of the fibroblastic and angioendothelial cells of cancer stroma. CONCLUSION: Activated or overexpressive MAPK activates the immediately-early oncogenes(c-fos, c-jun), which might play an important role in carcinogenesis of breast cancer and be an early event of oncogenesis of breast cancer. |
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