| 尼莫地平片剂人体药代动力学及生物利用度 |
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| 引用本文： | 侯淑贤 陈骐. 尼莫地平片剂人体药代动力学及生物利用度[J]. 沈阳药科大学学报, 1997, 14(2): 115-117 |
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| 作者姓名： | 侯淑贤 陈骐 |
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| 作者单位： | 同济医科大学基础医学院，沈阳药科大学药物研究所，辽阳市化纤总厂职工医院，同济医大附属医院，武汉职工医学院，沈阳中心血站 |
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| 摘 要： | 报告１０名男性健康志愿受试者随机交叉口服尼莫地平试验片和参比片各１２０ｍｇ的药代动力学和相对生物利用度．试验片和参比片Ｃｍａｘ分别为（３９１．８４±１４７．５２）和（３６８．９７±１７３．６６）μｇ／Ｌ，Ｔｍａｘ分别为（０．５５±０．１８）和（０．６４±０．２９）ｈ，ＡＬＬＣ分别为（７９０．８３±２０６．９６）和（７８４．０３±１９３．４３）μｇ／Ｌ·ｈ．统计学检验二者无显著性差异（Ｐ＞０．０５）．试验片的人体相对生物利用度为１０１．５０％±１４．００％，变异系数为１３．７０％．
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| 关 键 词： | 尼莫地平；药物动力学；生物利用度 |
Pharmacokinetics and Bioavailability of Nimoldopine Tablet in Normal Volunteers |
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| Hou Shuxian,Dai Zongshun,Cong Rong,Li Renli,Ai Yongxun,Chen Qi,Zao Guizhen,Tong Cengshu,Yang Xuefu. Pharmacokinetics and Bioavailability of Nimoldopine Tablet in Normal Volunteers[J]. Journal of Shenyang Pharmaceutical University, 1997, 14(2): 115-117 |
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| Authors: | Hou Shuxian Dai Zongshun Cong Rong Li Renli Ai Yongxun Chen Qi Zao Guizhen Tong Cengshu Yang Xuefu |
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| Abstract: | Pharmacokinetics and bioavailability of nimoldipine tablets were investigated in 10 normal healthy male volunteers,with each subject receiving a single dose of 120 mg of nimoldipine test tablets and 120 mg of nimoldipine reference tablets in a randomised crossover sequence.C max of nimoldipine was (391 84±147 52)μg/L for the test tablets and (368 97±173 66)μg/L for the reference tablets.T max of nimoldipine was (0 55±0 18) h for the test tablets and (0 64±0 29)h for the reference tablets.AUC of nimoleipine was (790 83±206 96)μg/L·h for the reference tablets.Signiticant difference between the test tablets and the reference tablets was not found( P >0 05).The relative bioavailability for nimoldipine test tablet was (101 50±14 00)%.(CV=13 70%). |
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| Keywords: | nimoldipine pharmacokinetics bioa vailability |
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