| 甲壳胺-硝苯地平速释片的制备及生物利用度 |
| |
| 引用本文： | 王中彦,胡成亚.甲壳胺-硝苯地平速释片的制备及生物利用度[J].沈阳药科大学学报,1997,14(2):79-82. |
| |
| 作者姓名： | 王中彦 胡成亚 |
| |
| 作者单位： | 沈阳药科大学基础部，沈阳市皇姑区中心医院 |
| |
| 基金项目： | 国家医药局重点科研课题 |
| |
| 摘 要： | 报道了用硝苯地平（ＮＦ）和甲壳胺（ＣＴＳ）共同研磨后制备ＮＦ速释片的工艺．ＮＦ速释片与市售片剂的溶出度试验表明，其体外累积溶出百分率经０．５ｈ分别为８０％和不足２０％，人口服两片剂的对照试验表明，ＮＦ速释片组体内达峰明显缩短，生物利用度也有显著提高．
|
| 关 键 词： | 硝苯地平 研磨混合物 溶出度 生物利用度 |
The Preparation and the Bioavailability of Chitosan Nifedipine Immediate Released Tablets |
| |
| Wang Zhongyan,Hu Liangcai,Zhu Yajian,Li Xinru,Hu Chengya.The Preparation and the Bioavailability of Chitosan Nifedipine Immediate Released Tablets[J].Journal of Shenyang Pharmaceutical University,1997,14(2):79-82. |
| |
| Authors: | Wang Zhongyan Hu Liangcai Zhu Yajian Li Xinru Hu Chengya |
| |
| Abstract: | A new technique was used to prepare quick releasing nifedipine(NF) tablets by co grinding with chitosan(CTS).The dissolutionrates of CTS NF tablets and NF tablets on the market were 80% and <20% in 0 5 h respectively.Shorter T max and bigger AUC proved obviouse by pharmacokinetic control experiments,one group receiving CTS NF tablets and the other group taking the market NF tablets. |
| |
| Keywords: | nifedipine ground mixture dissolution rates bioavailability |
| 本文献已被 CNKI 维普 等数据库收录！ |
