肾移植术后并发恶性肿瘤的临床分析

目的 总结肾移植患者恶性肿瘤的发病情况，探讨防治措施。方法 对1037例1113次肾移植的临床资料进行回顾分析。结果 在1037例肾移植患者中，发现15例恶性肿瘤，发病率为1．4％，其中肝癌最多(6／15)，其次是Kaposi肉瘤(4／15)，再其次是肺癌(2／15)。治疗方法主要是手术切除、减少免疫抑制剂的用量、放疗和化疗，现存活4例。结论 肾移植患者恶性肿瘤的发病率较一般人群高，治疗的效果取决于早期发现肿瘤并及早施行手术；在维持移植肾功能正常的前提下，尽可能的减少免疫抑制剂用量。

Malignant tumor following renal transplantation

Objective To summarize the occurrence of malignant tumor following renal transplantation and investigate the measures of prevention and treatment.Methods The clinical data of 1 037 cases of renal transplantation in our centre between Dec. 1979 and May 2001 were retrospectively. Results Of the 1 037 cases of renal transplantation, 15 cases were diagnosed as having malignant tumor with the incidence being 1.4% . The most common types of tumor were liver cancer (6/15), followed by Kaposi's sarcoma (4/15), pulmonary cancer (2/15). The main treatments included surgical resection, reducing the dosage of immunosuppressants, radiotherapy and chemotherapy.Conclusion There is higher incidence of malignance in the renal transplantation recipient than general crowd. The effect of treatment depended on early diagnosis of cancer and early surgical operation. At the same time, the dosage of immunosuppressants was reduced to maintain normal function of the graft.