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目的 探讨急性胆红素脑病的磁共振成像(MRI)特征及其与预后的关系.方法 回顾性分析2006年5月至2008年4月温州医学院附属第二医院暨育英儿童医院新生儿科11例急性胆红素脑病患儿的头颅MRI图像,以同期6例正常新生儿头颅MRI作对照.结果 11例急性胆红素脑病中,8例双侧苍白球在T1WI呈对称性高信号,在T2WI呈正常的稍高信号,其余3例未见明显异常.对5例急性胆红素脑病患儿进行了随访研究,初次MRI异常的3例诊断为手足徐动型脑性瘫痪,其双侧苍白球T1WI上的高信号消失,T2WI上正常的稍高信号转为对称性高信号;初次MRI正常和异常各1例,临床随访神经发育均正常.结论 双侧苍白球在T1WI呈对称性高信号是急性胆红素脑病相时特征性表现,由于病例数较少,MRI图像特征与临床预后的关系尚须进一步研究.

Acute bilirubin encephalopathy: MRI features and their correlation with prognosis

??Abstract:Objective??To study the MRI features in acute bilirubin encephalopathy and to determine their correlation with prognosis . Methods??The MR imagings in 11 cases of acute bilirubin encephalopathy were retrospectively studied?? which were compared with 6 healthy neonates. Results??Eight out of 11 cases of acute bilirubin encephalopathy demostrated symmetric??high-intensity signal in the the globus pallidus on T1-weighted imaging?? no lesions were detected on T2WI. Three cases of acute bilirubin encephalopathy with abnormal initial MRI findings had final diagnosis as athetoid cerebral palsy and demonstrated a signal switch from hypersignal in the globus pallidus on T1WI to hypersignal on T2WI. One case with abnormal initial MRI and 1 case with normal initial MRI of acute bilirubin encephalopathy displayed normal followed-up neurological development. Conclusion??The bilateral??symmetric??high-intensity signal in the globus pallidus on T1WI is probably characteristic MRI findings of acute bilirubin encephalopathy?? however?? it does not correlate with long-term prognosis.