Development of the human principal sensory trigeminal nucleus: a morphometric analysis |
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| Institution: | 1. Division of Neurology, Saitama Children''s Medical Center, 2100 Magome, Iwatsuki, Saitama 339, Japan;2. Department of Anatomy, Showa University School of Medicine, Showa, Japan;3. Faculty of Science of Living, Osaka City University, Osaka, Japan;4. Department of Pediatrics, Jikei University School of Medicine, Jikei, Japan;1. Department of Anesthesiology, University of California, San Diego, La Jolla, CA, USA;2. VA San Diego Healthcare System, La Jolla, CA, USA;3. Department of Anesthesiology and Pain Medicine, Seoul St. Mary’s Hospital, Catholic University of Korea, Seoul, South Korea;4. Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA;5. Department of Anesthesiology and Pain Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, Seoul, South Korea;1. Research Laboratory for Stereology and Neuroscience, Bispebjerg-Frederiksberg Hospital, Copenhagen, Denmark;2. Institute of Clinical Medicine, Faculty of Health, University of Copenhagen, Copenhagen, Denmark;1. Division of Neurobiology and Anatomy, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8510, Japan;2. Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh;3. Transdisciplinary Research Program, Niigata University, Niigata 951-8510, Japan;4. Division of Oral Physiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8514, Japan;1. Developmental Neurosciences Programme (Pain Research), UCL Great Ormond Street Institute of Child Health, London, UK;2. Neuroscience, Physiology and Pharmacology, University College London, London, UK;3. Department of Anaesthesia and Pain Medicine, Great Ormond Street Hospital NHS Foundation Trust, London, UK;1. Department of Histology and Embryology, Faculty of Medicine, Karabuk University, Karabuk, Turkey;2. Department of Histology and Embryology, Faculty of Medicine, Okan University, Istanbul, Turkey |
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| Abstract: | The anatomical development of the principal sensory trigeminal nucleus was assessed with morphometric features using serial celloidin sections of 15 human brains, including 12 brains obtained from fetuses and neonates. A microscope and an optical electronic planimeter combined with a computer were employed for morphometric measurements of columnar areas, neuronal numbers, neuronal areas and neuronal perimeters to statistically analyze and evaluate the development of neuronal densities, neuropil indexes and circularity ratios. We could not detect the principal sensory trigeminal nucleus in the specimen of 12 gestational weeks (GW). Microscopic observation disclosed that the fetal principal sensory trigeminal neurons approached those of the adult around 33 GW in terms of cell arrangements, amounts of Nissl bodies and morphology of neurons. Our morphometric analysis showed that the columnar volume, the neuronal area and the neuropil index increased with gestational age. The neuronal density decreased with gestational age, especially from 16 to 32 GW. Comparing the neuronal area with the columnar volume, it developed before the columnar volume during the fetal period. The neurons of the principal sensory trigeminal nucleus matured around 33 GW under microscopic observation and in terms of the distribution of neuronal areas. The development of the neuropil may accelerate after individual neurons of principal sensory trigeminal nucleus mature. |
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