Enhanced release of oxazepam from tablets containing solid dispersions |
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| Institution: | 1. Key Laboratory of Geotechnical and Underground Engineering of Ministry of Education, Department of Geotechnical Engineering, Tongji University, Shanghai 200092, China;2. Department of Geotechnical Engineering, College of Civil Engineering, Tongji University, Shanghai 200092, China;3. Collaborative Innovation Center of Geohazard Prevention (CICGP), Chengdu, Sichuan 610059, China;4. Department of Civil and Environmental Engineering, The Hong Kong University of Science and Technology, Hong Kong, China;5. China Shipbuilding NDRI Engineering Co. Ltd, Shanghai 200333, China;6. College of Civil Engineering, Huaqiao University, Quanzhou, Fujian 362021, China;1. School of Natural Sciences - Chemistry, University of Tasmania, Hobart, TAS, Australia;2. School of Chemistry and Molecular Bioscience, University of Wollongong, Molecular Horizons Research Institute, Wollongong, NSW, Australia;3. School of Chemistry, University of Bristol, Bristol, United Kingdom;4. Department of Chemistry, University of Otago, Dunedin, New Zealand;5. Centre for Biomedical and Chemical Sciences, School of Science, Auckland University of Technology, Auckland, New Zealand;6. The MacDiarmid Institute for Advanced Materials and Nanotechnology, Victoria University of Wellington, Wellington, New Zealand;7. Department of Biotechnology, Chemistry and Pharmaceutical Sciences, Università degli Studi di Siena, Siena, Italy;8. School of Chemical Sciences, University of Auckland, Auckland, New Zealand;1. Department of Chemistry, College of Science, Raparin University, Sulaimanyah 46012, Iraq;2. Department of Chemistry, College of Science, Salahaddin University, Erbil 44002, Iraq;3. Department of Chemistry, R.T.M. Nagpur University 440033, India;4. Post-Graduate and Research Department of Chemistry, The New College (Autonomous), University of Madras, Chennai 600 014, India;5. Laboratory of Applied Chemistry & Environment, Faculty of Sciences, Mohammed Premier University, MB 524, Oujda 60000, Morocco;6. Laboratory of Applied Organic Chemistry LCOA, Synthesis of Biomolecules and Molecular Modelling Group, Badji-Mokhtar - Annaba University, Box 12, Annaba 23000, Algeria;7. Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, Johor Bahru, Johor 81310, Malaysia;1. Psychiatry Department, Wroclaw Medical University, Poland;2. Nephrology and Transplantology Department, Wroclaw Medical University, Poland |
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| Abstract: | Solid dispersions of different ratios of Gelita collagel as the carrier and lactose were prepared by the spray drying method. Dissolution studies have shown that by preparing solid dispersions the dissolution rate and the solubility of oxazepam increase markedly, independent of the ratio of drug, carrier and lactose. The properties of the solid dispersions were characterized by X-ray diffraction and polarizing microscopic studies. An amorphous form of all prepared solid dispersions were indicated in X-ray studies. Tablets of solid dispersions of oxazepam/Gelita Collagel, physical mixtures and the drug alone were prepared. The best results from the dissolution test were obtained for tablets containing solid dispersions. They remained in good physical properties when stored for one year in normal conditions. |
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