BRCA-mutant pancreatic ductal adenocarcinoma |
| |
| Authors: | Eleonora Lai Pina Ziranu Dario Spanu Marco Dubois Andrea Pretta Simona Tolu Silvia Camera Nicole Liscia Stefano Mariani Mara Persano Marco Migliari Clelia Donisi Laura Demurtas Valeria Pusceddu Marco Puzzoni Mario Scartozzi |
| |
| Institution: | 1.Medical Oncology Unit, University Hospital and University of Cagliari, Cagliari, Italy ;2.Medical Oncology Unit, Sapienza University of Rome, Rome, Italy ;3.Department of Medical Oncology, Institut Jules Bordet—Université Libre de Bruxelles (ULB), Brussells, Belgium ;4.Department of Medical Oncology, San Raffaele Scientific Institute, Milan, Italy |
| |
| Abstract: | Despite continued research, pancreatic ductal adenocarcinoma (PDAC) remains one of the main causes of cancer death. Interest is growing in the role of the tumour suppressors breast cancer 1 (BRCA1) and BRCA2—typically associated with breast and ovarian cancer—in the pathogenesis of PDAC. Indeed, both germline and sporadic mutations in BRCA1/2 have been found to play a role in the development of PDAC. However, data regarding BRCA1/2-mutant PDAC are lacking. In this review, we aim to outline the specific landscape of BRCA-mutant PDAC, focusing on heritability, clinical features, differences between BRCA1 and 2 mutations and between germline and sporadic alterations, as well as established therapeutic strategies and those that are still under evaluation.Subject terms: Gastrointestinal cancer, Cancer genetics |
| |
| Keywords: | |
|
|
