Decrease of bone formation in adult women with fragility fractures |
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| Institution: | 1. Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD, the Netherlands;2. Department of Oral and Maxillofacial Surgery, Erasmus MC, University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD, the Netherlands;3. The Generation R Study, Erasmus MC, University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015, GD, the Netherlands;4. Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD, the Netherlands;1. Department of Trauma and Orthopaedic Surgery, Division of Orthopaedics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;2. Institute of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;3. Institute of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;1. BIO;2. Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Torino, Italy;3. INSIGNEO Institute for In Silico Medicine, University of Sheffield, Sheffield, UK;4. Faculty of Health, Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, UK;5. Department of Mechanical Engineering, University of Sheffield, Sheffield, UK |
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| Abstract: | Objectives: To compare bone mineral density (BMD) and some markers of bone metabolism in women with fragility fractures and in normal age-matched subjects. Methods: A 100 women with at least one vertebral deformity >25%, and 219 age-, BMI- and parity-matched healthy women, were recruited for the study. In all the patients fractures were symptomatic and occurred at least 1 year before densitometric measurement. Forearm bone mineral density (BMD) as well as biochemical assessment of some markers of bone turnover were measured in all the subjects. Results: BMD was significantly lower in the fracture than in the control group (0.326 ± 0.073 vs. 0.379 ± 0.079; P<0.001). Fractured women showed alkaline phosphatase (ALP) and osteocalcin (OC) serum levels significantly lower than controls, while no differences were found in fasting urinary calcium and hydroxyproline excretion. Women without fractures showed a significant correlation between ALP and both age and years since menopause (YSM). Such a correlation is lacking in the fracture group. Conclusions: Women with vertebral deformities likely due to a fracture had a forearm BMD and markers of bone formation lower than normal. Whether low bone density is due to a low peak of bone mass or to an increased postmenopausal bone loss sustained by an uncoupling between the two bone remodelling processes is still unclear. |
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