伴高尿酸血症的 IgA 肾病临床与病理分析

目的：探究伴高尿酸血症的 IgA 肾病临床与病理特征，分析其相关因素。方法将190例原发性IgA 肾病患者分为血尿酸正常组及高尿酸血症组，对比分析2组临床和病理特征。结果 IgA 肾病患者高尿酸血症的患病率为33.16%。高尿酸血症组与血尿酸正常组在性别、BMI、血压、血脂、血清胱抑素 C（Cys-C）、肌酐（Scr）、尿蛋白量、Lee 分级、肾小球球性硬化、肾小管间质损害、肾小动脉病变程度方面差异存在统计学意义。结论 IgA 肾病患者较易发生高尿酸血症，与血尿酸正常者相比，临床表现和肾脏病理损伤更为严重，提示高尿酸血症与 IgA 肾病预后相关。

Pathological analysis of IgA nephropathy patients with hyperuricemia

Objective To explore the clinical and pathological characteristics of IgA nephropathy patients with hyperuricemia and analyze its related factors. Methods The 190 cases of primary IgA nephropathy were divided into to two groups:the group with hyperuricemia and the group with not. A comparative analysis of clinical and pathological characteristics was performed between the two groups. Results The prevalence rate of hyperuricemia in IgA nephrop-athy was 33. 16% . There were remarkable differences between the two groups in gender,BMI,blood pressure,blood lipids,Cys-C,Scr,urine protein,Lee’s classification,glomerulosclerosis,tubulointerstitial injury and renal artery le-sions. Conclusion IgA nephropathy is prone to hyperuricemia. Clinical manifestations and renal pathological lesions in IgA nephropathy patients with hyperuricemia are more severe than those of normal uric acid,which suggests that hy-peruricemia is associated with the prognosis of IgA nephropathy.