Anticryptosporidial activity of furan derivative G1 and its inclusion complex with beta-cyclodextrin |
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Authors: | Castro-Hermida J A Gómez-Couso H Ares-Mazás M E Gonzalez-Bedia M M Castañeda-Cancio N Otero-Espinar F J Blanco-Mendez J |
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Institution: | Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain. |
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Abstract: | The capacity of beta-cyclodextrin (betaCD) to form a complex with a new furanic derivative, G1, was investigated. Interactions of the drug and betaCD in solution and in the solid state were studied using phase solubility techniques, thermal methods, X-ray, and IR spectroscopy. Preparation of a kneaded mix of G1/betaCD increased both the aqueous solubility and the dissolution rate of the furan derivative. The anticryptosporidial efficacies of the drug and of the inclusion complex were evaluated using a suckling murine model. Oral administration of G1 considerably decreased the intensity of the infection, but betaCD showed similar anticryptosporidial activity to that of the betaCD-G1 complex and higher activity than G1 alone. |
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