辛伐他汀联合缬沙坦治疗慢性心力衰竭患者的疗效及对脑钠尿肽和心功能的影响

目的　观察辛伐他汀联合缬沙坦治疗慢性心力衰竭(CHF)患者的疗效及对脑钠尿肽(BNP)和心功能的影响.方法96例CHF患者按随机数字表法分为两组,对照组48例给予常规治疗,观察组48例在常规治疗的基础上给予辛伐他汀联合缬沙坦治疗,两组疗程均为6个月.比较两组的临床疗效及BNP和心功能的变化.结果治疗后观察组总有效率[85.4％(41/48)]高于对照组[　70.8％(34/48)],但差异无统计学意义(P＞0.05).两组治疗前BNP、左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)和左室射血分数(LVEF)比较差异无统计学意义(P＞0.05).治疗后两组BNP、LVESD、LVEDD明显下降,LVEF明显升高,差异均有统计学意义(P＜　0.05).观察组治疗后BNP、LVESD、LVEDD低于同期对照组[(0.72±0.14)　μg/L比(1.21±0.22)　μg/L,(36.14±3.92)　mm比(41.32±4.22)　mm,(46.85　±4.11)　mm比(54.31±4.96)　mm],LVEF高于同期对照组[(44.62±3.38)％比(41.28±2.25)％],差异均有统计学意义(P＜0.05).结论辛伐他汀联合缬沙坦治疗CHF患者,能够提高临床疗效,降低血清BNP,改善患者的心功能,值得临床推广应用.

Clinical effect of simvastatin combined with valsartan in treatment of chronic heart failure and its affection on brain natriuretic peptide and heart function

Objective To observe the effect of simvastatin combined with valsartan in treatment of chronic heart failure(CHF) and its affection on brain natriuretic pepfde(BNP) and heart function.Methods Ninety-six cases of CHF patients were classified into two groups by random digits table,which control group of 48 cases were treated with normal therapy,and observation group of 48 cases were treated with simvastatin combined with valsartan at the base of normal therapy.The clinical effect,BNP and heart function between two groups were compared.Results The clinical effective rate in observation group and control group was 85.4％ (41/48) and 70.8％ (34/48) (P ＞ 0.05).The levels of BNP,left ventricular end-systolic dimension (LVESD),left ventricular end-diatolic dimension (LVEDD) and left ventricular ejection fraction (LVEF)after treatment were (0.72 ± 0.14) μ g/L,(36.14 ± 3.92) mm,(46.85 ± 4.11 )mm and (44.62 ± 3.38)％ in observation group,while ( 1.21 ± 0.22 ) μ g/L,(41.32 ± 4.22 ) mm,(54.31 ± 4.96 ) mm and (41.28 ± 2.25 )％in control group.After treatment,the levels of BNP,LVESD and LVEDD were significantly decreased,LVEF was significantly higher in both groups (P＜ 0.05).Moreover,the levels of BNP,LVESD and LVEDD in observation group were significantly lower than those in control group (P＜ 0.05),LVEF was significantly higher than that in control group (P＜ 0.05 ).Conclusion Simvastatin combined with valsartan in treatment of CHF can enhance the clinical effect,decrease BNP level and improve heart function,which can be applied in clinic.