普罗布考联合阿托伐他汀治疗狭窄性颈动脉粥样硬化斑块的临床研究

目的　观察普罗布考联合阿托伐他汀治疗狭窄性颈动脉粥样硬化斑块的临床效果.方法将86例狭窄性颈动脉粥样硬化患者按随机数字表法分为两组,观察组43例采用普罗布考联合阿托伐他汀治疗,对照组43例仅采用阿托伐他汀治疗,两组疗程均为6个月,比较两组治疗前后的动脉粥样硬化情况和血脂的变化.结果治疗前两组斑块面积、内膜-中层厚度(IMT)比较差异无统计学意义(P＞0.05).观察组治疗后斑块面积和IMT显著降低(P＜0.05),而对照组治疗后斑块面积和IMT与治疗前比较差异无统计学意义(P＞0.05).观察组治疗后斑块面积和IMT显著低于同期对照组,差异有统计学意义(0.59±0.19)　cm2比(0.72±0.28)　cm2,(2.76±0.4-1)　mm比(3.27±0.57)　mm,P＜0.05].两组治疗前总胆固醇(TC)、三酰甘油(G)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(　HDL-C)水平比较差异均无统计学意义(P＞0.05),治疗后两组TC、TG、LDL-C水平显著下降,HDL-C水平显著升高,差异均有统计学意义(P＜0.05).观察组治疗后TC、TG、LDL-C水平显著低于同期对照组(P＜0.05),HDL-C水平显著高于同期对照组(P＜0.05).结论普罗布考联合阿托伐他汀治疗狭窄性颈动脉粥样硬化斑块,能够明显改善颈动脉粥样硬化,降低血脂,值得临床推广应用.

Clinical study of probucol combined with atorvastatin in treatment of stenosis carotid atherosclerosis

Objective To observe the effect of probucol combined with atorvastatin in treatment of stenosis carotid atherosclerosis.Methods Eighty-six patients with stenosis carotid atherosclerosis were separated into two groups with 43 cases each by random digits table.The patients were treated with probucol combined with atorvastatin in observation group and atorvastatin only in control group.The changes of arteriosclerotic plaque and blood fat pre- and poet-treatment were observed.Results There was no significant difference in the levels of lumen area (LN) and intima-media thickness (IMT) pre-treatment between two groups (P＞ 0.05).Compared with pre-treatment,the levels of LN and IMT post-treatment were significantly decreased in observation group(P ＜ 0.05 ),while no significant difference in control group (P ＞0.05).There was significant difference in the levels of LN and IMT post-treatment between two groups (0.59 ±0.19) cm2 vs.(0.72 ±0.28) cm2,(2.76 ±0.41 ) mm vs.(3.27 ±0.57) mm](P＜ 0.05).There was no significant difference in the levels of total cholesterol (TC),triacylglycerol (TG),low density lipoprotein cholesterol (LDL-C),high density lipoprotein cholesterol (HDL-C) pre-treatment between two groups (P ＞0.05).Compared with pre-treatment,the levels of TC,TG,LDL-C post-treatment were decreased,HDL-C was increased,there were significant differences (P ＜ 0.05 ).Post-treatment,the levels of TC,TG,LDL-C in observation group were lower and HDL-C was higher than those in control group (P ＜ 0.05).Conclusion Probucol combined with atorvastatin in treatment of stenosis carotid atherosclerosis can improve arteriosclerotic plaque and low blood fat,which can be applied in clinic.