前列地尔脂质体联合黄芪注射液治疗肝肾综合征的临床对照研究

目的 研究前列地尔脂质体(Lipo PGE1)联合黄芪注射液治疗肝肾综合征(HRS)的疗效.方法 回顾性分析应用Lipo PGE1联合黄芪注射液治疗的26例HRSⅡ型患者(治疗组)的临床资料,并与采用常规的保肝、利尿、对症支持治疗的28例HRSⅡ型患者(对照组)进行比较.结果治疗组总有效率88.5％(23/26),对照组总有效率64.3％(18/28),两组比较差异有统计学意义(P＜0.05).两组患者治疗后丙氨酸氨基转移酶(ALT)、总胆红素(TBIL)、凝血酶原活动度(PTA)较治疗前均有显著改善,差异有统计学意义(P＜0.05)；治疗组治疗后ALT、PTA与对照组比较差异有统计学意义(P＜0.05),但TBIL与对照组比较差异无统计学意义(P＞0.05).两组患者治疗后内生肌酐清除率、血尿素氮、血肌酐及24h尿蛋白定量较治疗前有显著改善(P＜0.05),且治疗组明显优于对照组(P＜0.05).结论 Lipo PGE1联合黄芪注射液治疗HRS,可明显提高疗效,有效恢复肝肾功能,应在临床工作中推广使用.

Clinical control study on liposomes of alprostadil combined with huangqi injection in treatment of hepatorenalsyndrome

Objective To observe the clinical curative effects on liposomes of alprostadil (Lipo PGE1)combined with huangqi injection in the treatment of the patients with hepatorenal syndrome (HRS).Methods Retrospective analysis was made on 26 patients with HRS Ⅱ (treatment group) who were treated with Lipo PGE1 combined with huangqi injection,and compared with 28 patients (control group) whoreceived normal liver protection,diuretics,symptomatic and supporting treatment.Results Total effective rate in treatment group 88.5％ (23/26) ] was significantly higher than that in control group 64.3％ ( 18/28 ) ](P ＜ 0.05 ).After treatment,alanine aminotransferase (ALT),total bilirubin (TBIL),prothrombin activity ( PTA ) were significantly improved compared with before treatment in two groups(P ＜ 0.05 ).After treatment,ALT,PTA had significant difference in two groups (P＜ 0.05 ),and TBIL had no significant difference in two groups (P＞0.05).Creatinine clearance rate(CCr),blood urea nitrogen(BUN),serum creatinine(SCr) and 24 hours urinary protein quantitative defermination was significantly improved in two groups after treatment (P ＜ 0.05 ),and the degree of improvement had significant difference (P ＜ 0.05 ).Conclusion Lipo PGE1 combined with huangqi injection in treating the patients with HRS can significantly improve the clinical curative effects,restore renal and liver function,and should be used in clinical work.