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实时心肌声学造影定量评价不同程度心肌缺血的实验研究
引用本文:韩增辉,钱蕴秋,苏海砾,贺建国. 实时心肌声学造影定量评价不同程度心肌缺血的实验研究[J]. 中国超声医学杂志, 2002, 18(1): 9-12
作者姓名:韩增辉  钱蕴秋  苏海砾  贺建国
作者单位:第四军医大学西京医院超声诊断科,西安市,710032
摘    要:目的:探讨实时心肌声学造影定量诊断不同程度心肌缺血的可行性。方法:12只开胸犬以冠脉缩窄器造成左前降支轻,中,重不同程度狭窄,狭窄前后静滴“全氟显”(速度5ml/min)进行实时心肌声学造影。左室乳头肌中段短轴观察左室前壁心肌显影,室壁厚度和运动,采用动态图像单帧转化法以图像软件分析造影结果。结果:轻度缺血时,心肌显影的视频亮度峰值(VBP)及再灌注速度与狭窄前比较无显著差异,药物负荷状态下差异增大;中,重度缺血时二者明显减低。心肌缺血时,舒张期与收缩期VBP比值正常减低。结论:结合药物负荷,实时心肌声学造影可以定量诊断不同程度心肌缺血。

关 键 词:心肌声学造影 冠脉狭窄 心肌灌注 实验研究

Experimental Study on the Quantitative Assessment of Canine Graded Coronary Stenosis with Real-time Myocardial Contrast Echocardiography
Abstract:Objective:To evaluate the feasibility of real time MCA in the quantitative assessment of canine graded coronary stenosis.Methods:Three grades,mild,moderate and severe of left anterior desending coronary artery(LAD)were produced in twelve open chest canine models.Real time MCE,using intravenous infusion(3ml/min)of a perfluorocarbon contrast agent,was performed before and after stenosis.Myocardial contrast perfusion and wall motion function of left ventricular anterior wall were observed.The results of contrast perfusion were analysed with an imaging software by measuring the vedio bright peak(VBP)of the perfusion.Results:Compared to the non flow limiting at rest,there were no obivous changes on both VBP and contrast replenishment velocity in the mild stenosis grade.Both of them,however,were decreased slightly during dobutamine stress.In moderate and severe stenosis grade,VBP and replenishment velocity were decreased markedly,and the ratio of VBP between diastole and systole were decreased lower than normal.Conclusions:With the help of dobutamine stress,real time MCE can provide accurate quantification of coronary stenosis.
Keywords:Myocardial contrast echocardiography Coronary artery stenosis Myocardial perfusion  
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