子宫内膜异位症性不孕症患者血清和腹腔液中CA_(125)和抗转铁蛋白抗体水平

目的:探讨CA125和抗转铁蛋白抗体(TFAb)在子宫内膜异位症性不孕症患者血清和腹腔液中的水平。方法:选择91例不孕症患者,其中子宫内膜异位症患者31例(子宫内膜异位症组)、盆腔炎症患者30例(炎症组)、正常盆腔患者30例(对照组)。采用酶联免疫吸附法(ELISA)检测各组患者血清、腹腔液中CA125和TFAb的水平并进行比较。结果:子宫内膜异位症组血清和腹腔液中CA125水平均高于对照组及炎症组(P<0.01);重度子宫内膜异位症患者血清和腹腔液中CA125水平均明显升高(P<0.01),而轻度子宫内膜异位症患者仅腹腔液中CA125水平明显升高(P>0.05)。子宫内膜异位症组血清和腹腔液中TFAb阳性率均高于对照组及炎症组(P<0.01);轻、重度子宫内膜异位症患者血清和腹腔液中TFAb阳性率均高于对照组及炎症组(P<0.01)。结论:子宫内膜异位症导致不孕的机制可能与自身免疫反应有关;测定血清和腹腔液中的CA125和TFAb水平有利于子宫内膜异位症性不孕症的筛查及辅助诊断。

Levels of CA125 and anti-transferrin antibody in serum and peritoneal fluid of patients with endometriosis-associated infertility

Objective:To explore the levels of CA125 and anti-transferrin antibody in serum and peritoneal fluid of patients with endometriosis-associated infertility.Methods:Ninety one patients with infertility were selected and divided into endometriosis group(31 patients with endometriosis),inflammation group(30 patients with pelvic inflammation),and control group(30 patients with pelvic cavity).ELISA was used to detect the levels of CA125 and anti-transferrin antibody in serum and peritoneal fluid of patients in the three groups.Results:The levels of CA125 in serum and peritoneal fluid of endometriosis group were statistically significantly higher than those in control group and inflammation group(P<0.01);the levels of CA125 in serum and peritoneal fluid of patients with severe endometriosis increased significantly(P<0.01);while in patients with mild endometriosis,the level of CA125 in peritoneal fluid increased(P>0.05).The levels of anti-transferrin antibody in serum and peritoneal fluid of endometriosis group were statistically significantly higher than those in control group and inflammation group(P<0.01);the levels of anti-transferrin antibody in serum and peritoneal fluid of patients with mild and severe endometriosis were statistically significantly higher than those in control group and inflammation group(P<0.01).Conclusion:The mechanism of endometriosis-associated infertility may be correlated with autoimmune response;detecting the levels of CA125 and anti-transferrin antibody in serum and peritoneal fluid is helpful to screening and auxiliary diagnosis of endometriosis-associated infertility.