米非司酮、米索前列醇与清宫术三联治疗稽留流产64例临床观察

【摘要】目的探讨米非司酮、米索前列醇与清官术联合应用于稽留流产治疗的临床效果。方法选取本院2010年6月～2011年6月收治稽留流产患者128例，采用随机数字表法分为对照组和联合治疗组，每组64例，分别采用乙烯雌醇＋清官术和米非司酮＋米索前列醇＋清宫术治疗；比较两组患者手术时间、术中出血量、一次清宫成功率，镇痛及宫颈软化、扩张总有效率，人工流产综合征发生率等。结果联合治疗组患者手术时间及术中出血量均明显少于对照组（P〈0．05）；联合治疗组患者一次清宫成功率明显高于对照组（P〈0．05）；联合治疗组患者镇痛总有效率明显高于对照组（P〈0．05）；联合治疗组患者宫颈软化、扩张总有效率明显高于对照组（P〈0．05）；同时联合治疗组患者人丁流产综合症发生率明显低于对照组（P〈0．05）。结论米非司酮、米索前列醇联合清宫术三联治疗稽留流产能够减少术中创伤、提高镇痛效果及一次清宫成功率．降低不良反应发生风险。

Clinical observation of 64 cases of missed abortion treated by triple therapy of mifepristone, misoprostol and uterine curettage

Objective To investigate the effects of triple therapy of mifepristone, misoprostol and uterine curettage in treatment of missed abortion. Methods One hundred and twenty-eight cases of missed abortion patients who were treated in our hospital from June 2010 to June 201 l were randomly divided into control group and treatment group with 64 cases in each group by the method of random number table, the control group was treated by orgabolin and u- terine curettage, the treatment group was treated by mifepristone plus misoprostol plus uterine curettage. The operation time, intraoperative bleeding amount, one-time success rate, the total effective rate of analgesia, cervical softening and expanding, the occurrence of induced abortion syndrome and so on of two groups were compared. Results The opera- tion time and intraoperative bleeding amount of the treatment group patients were significantly less than that in control group （P 〈 0.05）, the one-time success rate and the total effective rate of analgesia, cervical softening and expanding of the treatment group patients was obvious higher than that in control group （P 〈 0.05）. At the same time, the occurrence of induced abortion syndrome of the treatment group patients was significantly lower than that of the control group （P 〈 0.05）. Conclusion Triple therapy of mifepristone, misoprostol and uterine curettage in the treatment of missed abortion can reduce intraoperative trauma, improve analgesia effect and one-time success rate, and reduce the risk of adverse reaction.