肿瘤标志物CA125检测在卵巢疾病诊断中的应用

目的:探讨CA125单项及联合CA199、CEA检测在卵巢癌及其他肿瘤诊断方面的价值。方法:应用ADVA Cen-taur和ADVIA Centaur XP全自动化学发光免疫分析仪测定647例患者及50例健康妇女的血清CA125和CA199、CEA,并对结果进行统计学分析。结果:647例患者CA125总阳性率为22.4%(145/647);卵巢癌CA125阳性率为81.0%(34/42);良性卵巢肿瘤CA125阳性率为18.8%(12/64);子宫内膜异位症CA125阳性率为62.5%(30/48);妇科其他疾病CA125的阳性率为11.8%(45/381),与正常妇女相比较有显著性差异(P<0.05)。结论:CA125对卵巢癌及其他肿瘤鉴别诊断有一定的意义,CA125与CA199及CEA联合检测可以提高卵巢癌诊断的敏感性。

Application of detection of tumor marker CA125 in diagnosis of ovarian diseases

Objective:To explore the clinical values of CA125 detection and joint detection of CA125,CA199,and CEA in diagnosis of ovarian cancer and other tumors.Methods:ADVA Centaur and ADVIA Centaur XP automatic chemiluminescence immunoassay were used to detect serum levels of CA125,CA199,and CEA in 647 patients and 50 healthy women,and then the results were analyzed retrospectively.Results:The total positive rate of CA125 in 647 patients was 22.4%(145/647);the positive rates of CA125 in patients with ovarian cancer,benign ovarian tumor,endometriosis,and other gynecological diseases were 81.0%(34/42),18.8%(12/64),62.5%(30/48),and 11.8%(45/381),respectively,compared with normal women,there was statistically significant difference(P<0.05).Conclusion:CA125 has a certain significance in differential diagnosis of ovarian cancer and other tumors,joint detection of CA125,CA199,and CEA can improve the diagnostic sensitivity of ovarian cancer.