不同剂量米非司酮在子宫内膜异位症治疗中的效果观察

目的比较不同剂量米非司酮在子宫内膜异位症中的疗效。方法选取2010年1月～2011年12月于本院进行治疗的64例子宫内膜异位症患者为研究对象，将其随机分为两组，A组的32例患者于月经周期第1天开始口服米非司酮12．5mg/d，连续服用6个月，B组的32例患者则于月经中期开始口服米非司酮6．25mg，d，服用4d．连续治疗6个月，后将两组患者治疗前后的激素水平及不良反应发生率进行比较。结果治疗后B组患者的血清孕酮（P）水平低于A组，且不良反应发生率低于A组，P〈0．05，而其他方面的激素差异无统计学意义．P〉0．05。结论小剂量米非司酮对子宫内膜异位症有较好的治疗作用，且不良反应发生率更低。

Observation on the effect of different dose mifepristone in the treatment of endometriosis

Objective To compare the effect of different dose mifepristone in the treatment of endometriosis. Methods Sixty-four patients with endometriosis in our hospital from January 2010 to December 2011 were selected as research object, and they were randomly divided into two groups, 32 cases of group A were treated with mifepristone 12.5 mg/d for 6 months at first day of the menstrual cycle, 32 cases of group B were treated with mifepristone 6.25 mg/d, 4 days in each menstrual cyclefor 6 months at first day of the menstrual cycle, then the hormones before and after the treat- ment and adverse reactions rate of two groups were compared. Results The serum Progesterone （P） of group B after the treatment was lower than that of group A, and the adverse reactions rate was lower than that of group A, P 〈 0.05, and other hormones of two groups had no significant differences, P 〉 0.05. Conclusion Low-dose mifepristone has better treatment effect for endometriosis, and the adverse reactions rate is lower.