2型糖尿病患者血Hcy水平相关影响因素分析

目的探讨2型糖尿病（T2DM）患者血同型半胱氨酸（Hcy）相关影响因素。方法收集近2年在本院住院的149例T2DM患者的临床资料,采用SPSS医学统计软件,通过t检验、多重线性回归分析（Stepwise法,逐步法）方法,回顾性分析血Hcy与血压、脂肪肝、空腹C肽（FCP）、三酰甘油（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-CH）、高密度脂蛋白胆固醇（HDL-CH）、血尿酸（UA）、糖化血红蛋白（HbA1c）、糖化血清蛋白（GSP）、纤维蛋白原（FIB）之间的关系。结果非高血压组与高血压组、非高血脂组与高血脂组、脂肪肝组与非脂肪肝组患者血Hcy水平均差异无统计学意义（P〉0.05）;血UA回归系数B=0.011,标准化回归系数（Beta）=0.259,t=2.279,P=0.026,回归系数95%CI（0.001,0.020）]与血Hcy存在线性依存关系,为正相关关系;自变量TG、TC、LDL-CH、HDL-CH、FCP、HBA1c、GSP、FIB未进入回归模型（P〉0.05）。结论 T2DM患者血Hcy水平受到血UA水平的影响,控制血UA水平有利于降低血Hcy。

Analysis of related factors of blood Hcy levels in type 2 diabetes patients

Objective To explore the related factors of plasma homocysteine （Hcy） levels in type 2 diabetic patients. Methods Clinical data of hospitalized patients of 149 cases diagnosed with type 2 diabetes in our hospital the last 2 years were collected. Used SPSS statistical software of medicine, by t-test, multiple linear regression analysis （Stepwise） method, retrospective analyzed of the relationship between blood Hcy and blood pressure, fatty liver, fasting C-peptide （FCP）, triglyceride （TG）, totalcholesterol （TC）, low-density lipoprotein （LDL-CH）, high-density lipoprotein （HDL-CH）, blood uric acid （UA）, glycosylated hemoglobin （HbA1c）, glycated serum protein （GSP）, FIB. Results Non-hypertension group and hypertension group, non-high cholesterol group and high cholesterol group, fatty liver group and non-fatty liver group, blood Hcy levels had no significant difference （P 0.05）; Blood UA regression coefficient B = 0.011, standardized regressioncoefficient （Beta） = 0.259, t = 2.279, P = 0.026, 95% CI （0.001,0.020）] was associated with blood Hcy by linear dependency relations, and having positive correlation; Independent variables of TG, TC, LDL-CH, HDL-CH, FCP, HBA1c, GSP and FIB not entering the regression model. Conclusion T2DM patients blood Hcy levels are effected by serum UA levels, controlling blood UA levels help to reduce blood Hcy.